Publication

Identification of ellagic acid rhamnoside as a bioactive component of a complex botanical extract with anti-biofilm activity

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Last modified
  • 02/20/2025
Type of Material
Authors
    Benjamin.M Fontaine, Emory UniversityKate Nelson, Emory UniversityJames T. Lyles, Emory UniversityParth B. Jariwala, Emory UniversityJennifer M. García-Rodriguez, Emory UniversityCassandra Quave, Emory UniversityEmily Weinert, Emory University
Language
  • English
Date
  • 2017-03-23
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2017 Fontaine, Nelson, Lyles, Jariwala, García-Rodriguez, Quave and Weinert.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-302X
Volume
  • 8
Issue
  • MAR
Start Page
  • 496
End Page
  • 496
Grant/Funding Information
  • National Institutes of Health10.13039/100000002 MARC Fellowship.
  • Emory University10.13039/100006939.
  • Georgia Research Alliance10.13039/100008065 GRA.VL 13.C7.
  • Emory University10.13039/100006939 Scholarly Inquiry and Research Grant.
Supplemental Material (URL)
Abstract
  • Staphylococcus aureus is a leading cause of hospital-acquired infections. It is listed among the top "serious threats" to human health in the USA, due in large part to rising rates of resistance. Many S. aureus infections are recalcitrant to antibiotic therapy due to their ability to form a biofilm, which acts not only as a physical barrier to antibiotics and the immune system, but results in differences in metabolism that further restricts antibiotic efficacy. Development of a modular strategy to synthesize a library of phenolic glycosides allowed for bioactivity testing and identification of anti-biofilm compounds within an extract of the elmleaf blackberry (Rubus ulmifolius). Two ellagic acid (EA) derivatives, EA xyloside and EA rhamnoside, have been identified as components of the Rubus extract. In addition, EA rhamnoside has been identified as an inhibitor of biofilm formation, with activity comparable to the complex extract 220D-F2 (composed of a mixture of EA glycosides), and confirmed by confocal laser scanning microscopy analyses.
Author Notes
Keywords
Research Categories
  • Biology, Molecular
  • Health Sciences, Pathology
  • Health Sciences, General

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