Body Composition and Bone Mineral Density in Patients With Heart Failure

• Type of Material: Article
• Authors: Demetrius A. Abshire, Washington State University; Debra K. Moser, University of Kentucky; Jody L. Clasey, University of Kentucky; Misook L. Chung, University of Kentucky; Susan J. Pressler, Indiana University; Sandra B Dunbar, Emory University; Seongkum Heo, University of Arkansas Medical Sciences; Terry A. Lennie, University of Kentucky
• Language: English
• Date: 2017-04-01
• Publisher: SAGE Publications (UK and US)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © The Author(s) 2016.
• Final Published Version (URL): http://dx.doi.org/10.1177/0193945916658885
• Title of Journal or Parent Work: Western Journal of Nursing Research
• ISSN: 0193-9459
• Volume: 39
• Issue: 4
• Start Page: 582
• End Page: 599
• Grant/Funding Information: This work was supported by the American Nurses Foundation; American Heart Association (0830104N); the University of Kentucky General Clinical Research Center (M01 RR002602); and the National Institute of Nursing Research (R01 NR009280 and P20 NR010679).
• Keywords: WOMEN; OLDER MEN; OSTEOPOROSIS; LEAN MASS; heart failure; FAT MASS; ESTROGEN; Life Sciences & Biomedicine; MUSCLE MASS; ASSOCIATION; bone mineral density; Science & Technology; FRACTURE RISK; Nursing; sarcopenia; LOOP DIURETICS; obesity
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, General

Abstract

The purpose of this study was to examine associations among bone mineral density, osteopenia/osteoporosis, body mass index (BMI), and body composition in patients with heart failure (HF). A total of 119 patients (age = 61 ± 12 years, 65% male) underwent dual-energy X-ray absorptiometry scans to determine bone mineral density and body composition. In multivariable linear regressions, BMI, relative skeletal muscle index (RSMI), and mineral-free lean mass were positively associated with total body bone mineral density. Mineral-free lean mass was most strongly associated with bone mineral density (β =.398). In multivariable logistic regressions, higher BMI, RSMI, and mineral-free lean mass were associated with lower odds for osteopenia/osteoporosis. Fat mass was not associated with total body bone mineral density or osteopenia/osteoporosis. These results suggest that muscle mass may be the important component of body mass associated with bone mineral density in patients with HF.