Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic

• Type of Material: Article
• Authors: Stefania Arasi, Bambino Gesù Children’s Hospital IRCCS; Ulugbek Nurmatov, Cardiff University; Paul J. Turner, Imperial College, London; Ignacio J. Ansotegui, Hospital Quironsalud Bizkaia; Shahd Daher, University of Oxford; Audrey Dunn-Galvin, University College Cork; Motohiro Ebisawa, Sagamihara National Hospital; Philippe Eigenmann, University Hospitals of Geneva; Montserrat Fernandez-Rivas, Hospital Clınico San Carlos; Ruchi Gupta, Northwestern University; Anna Nowak-Wegrzyn, New York University; Stavros Petrou, University of Oxford; Graham Roberts, University Hospital Southampton NHS Foundation Trust; Mario A. Sánchez Borges, Centro Médico Docente La Trinidad; Sayantani B. Sindher, Stanford University; Luciana Kase Tanno, Hospital Sírio Libanês; Marta Vazquez-Ortiz, Imperial College, London; Brian Vickery, Emory University; Gary Wing-Kin Wong, Chinese University of Hong Kong; Alessandro Fiocchi, Bambino Gesù Children’s Hospital IRCCS
• Language: English
• Date: 2020-12-01
• Publisher: ELSEVIER
• Publication Version: Final Published Version
• Copyright Statement: © 2020 Published by Elsevier Inc. on behalf of World Allergy Organization.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.waojou.2020.100493
• Title of Journal or Parent Work: WORLD ALLERGY ORGANIZATION JOURNAL
• Volume: 13
• Issue: 12
• Start Page: 100493
• End Page: 100493
• Grant/Funding Information: This is a project of the World Allergy Organization (WAO), supported by a grant from Novartis, as well as Abbott Laboratories and Food Allergy Research & Education (FARE). WAO will fund the systematic review to support the development of the international consensus on the definition of severe food allergy. The funder and supporters had no role in the development of the protocol nor will they have any role in the conduct of the systematic review or its publication.
• Keywords: Severity; Definition; Immunology; Classification; Science & Technology; ANAPHYLAXIS; Life Sciences & Biomedicine; RISK; Allergy; Food allergy
• Research Categories: Health Sciences, Immunology; Health Sciences, Medicine and Surgery

Abstract

Background and aims: The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published studies. Studies will be independently screened against pre-defined eligibility criteria and critically appraised by established instruments. Data will be descriptively and, if possible and applicable, quantitatively synthesised. Ethics and dissemination: This study does not require any specific ethical approval since it is a systematic review. We plan to report results from this systematic review in a peer reviewed journal. These results will be used to inform the development of an international consensus to define severe food allergy. Author's potential conflicts of interest are clearly stated. PROSPERO registration number: CRD42020183103.