Toward a Model for Arf GTPases as Regulators of Traffic at the Golgi

• Type of Material: Article
• Authors: Richard A Kahn, Emory University
• Language: English
• Date: 2009-12-03
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved
• Final Published Version (URL): http://dx.doi.org/10.1016/j.febslet.2009.10.066
• Title of Journal or Parent Work: FEBS Letters
• ISSN: 0014-5793
• Volume: 583
• Issue: 23
• Start Page: 3872
• End Page: 3879
• Grant/Funding Information: The author is supported by grants from the National Institutes of Health (R01 GM67226 and R01 GM61268).
• Keywords: Arf GAPs; Arf-like (Arl); Arf GEFs; Arf-dependent adaptors; ADP-ribosylation factor (Arf)

Abstract

In this review I summarize the likely roles played by Arf proteins in the regulation of membrane traffic at the Golgi, from the perspective of the GTPase. The most glaring limitations to the development of a coherent molecular model are highlighted; including incomplete information on the initiation of Arf activation, identification of the “accessory proteins” required for carrier maturation and scission, and those required for directed traffic and fusion at the destination membrane. Though incomplete, the molecular model of carrier biogenesis has developed rapidly in recent years and promises richness in understanding this essential process.