Translating Glycolytic Metabolism to Innate Immunity in Dendritic Cells

• Type of Material: Article
• Authors: Mario Cortese, Emory University; Charles Sinclair, Emory University; Bali Pulendran, Emory University
• Language: English
• Date: 2014-05-06
• Publisher: Elsevier (Cell Press): 12 month embargo
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2014 Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.cmet.2014.04.012
• Title of Journal or Parent Work: Cell Metabolism
• ISSN: 1550-4131
• Volume: 19
• Issue: 5
• Start Page: 737
• End Page: 739
• Keywords: Life Sciences & Biomedicine; Cell Biology; Endocrinology & Metabolism; Science & Technology; ACTIVATION
• Research Categories: Biology, Cell

Abstract

Growing evidence supports a role for glycolysis in immune activation. Everts et al. (2014) now show that TLR-mediated stimulation of dendritic cells rapidly induces glycolysis, which regenerates NADPH and TCA intermediates to support fatty acid production. This enhances ER and Golgi membrane synthesis and innate activation of dendritic cells.