Cytosines do it, thymines do it, even pseudouridines do it - Base flipping by an enzyme that acts on RNA

• Type of Material: Article
• Authors: Xiaodong Cheng, Emory University; Robert M. Blumenthal, Medical College of Ohio
• Language: English
• Date: 2002-02-01
• Publisher: Elsevier (Cell Press)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2002 Cell Press. Published by Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/S0969-2126(02)00710-4
• Title of Journal or Parent Work: Structure
• ISSN: 0969-2126
• Volume: 10
• Issue: 2
• Start Page: 127
• End Page: 129
• Keywords: Biophysics; Life Sciences & Biomedicine; Cell Biology; Science & Technology; Biochemistry & Molecular Biology
• Research Categories: Chemistry, Biochemistry

Abstract

In the December 28, 2001 issue of Cell, Hoang and Ferré-D'Amaré report the structure of a tRNA pseudouridine synthase, showing the target uridine flipped out from the tRNA and confirming that base flipping is not limited to enzymes that act on DNA.