Publication

The path to microRNA therapeutics in psychiatric and neurodegenerative disorders

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Last modified
  • 02/20/2025
Type of Material
Authors
    Anthony Chan, Emory UniversityJannet Kocerha, Yerkes National Primate Research Center
Language
  • English
Date
  • 2012-05-17
Publisher
  • Frontiers Research Foundation
Publication Version
Copyright Statement
  • © 2012 Chan and Kocerha
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-8021
Volume
  • 3
Issue
  • 82
Start Page
  • 1
End Page
  • 10
Grant/Funding Information
  • YNPRC is supported by the National Center for Research Resources P51RR165 and is currently supported by the Office of Research and Infrastructure Program (ORIP)/OD P51OD11132.
  • This study is supported by grant awarded by the ORIP/NIH (RR018827) and the American Recovery and Reinvestment Act (ARRA) Fund to Anthony W. S. Chan.
Abstract
  • The microRNA (miRNA) class of non-coding RNAs exhibit a diverse range of regulatory roles in neuronal functions that are conserved from lower vertebrates to primates. Disruption of miRNA expression has compellingly been linked to pathogenesis in neuropsychiatric and neurodegenerative disorders, such as schizophrenia, Alzheimer’s disease, and autism. The list of transcript targets governed by a single miRNA provide a molecular paradigm applicable for therapeutic intervention. Indeed, reports have shown that specific manipulation of a miRNA in cell or animal models can significantly alter phenotypes linked with neurological disease. Here, we review how a diverse range of biological systems, including Drosophila, rodents, and primates such as monkeys and humans, can be integrated into the translation of miRNAs as novel clinical targets.
Author Notes
  • Correspondence: Jannet Kocerha, Yerkes National Primate Center, Emory University, 954 Gatewood Road North East, Atlanta, GA 30329, USA. e-mail: jannet.kocerha@emory.edu
Research Categories
  • Biology, Neuroscience

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