MicroRNA in myogenesis and muscle atrophy

• Type of Material: Article
• Authors: Xiaonan Wang, Emory University
• Language: English
• Date: 2013-05
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Lippincott Williams & Wilkins; © 2013 Wolters Kluwer Health
• Final Published Version (URL): http://journals.lww.com/co-clinicalnutrition/pages/articleviewer.aspx?year=2013&issue=05000&article=00005&type=abstract
• Title of Journal or Parent Work: Current Opinion in Clinical Nutrition and Metabolic Care
• ISSN: 1363-1950
• Volume: 16
• Issue: 3
• Start Page: 258
• End Page: 266
• Grant/Funding Information: This work was supported by NIH NIAMS 1R01AR060268 and the NNSF of China (30971471) to X.W.
• Keywords: muscle regeneration; proliferation and differentiation; insulin-like growth factor; muscle wasting; hypertrophy/atrophy
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Purpose of review To understand the impact of microRNA on myogenesis and muscle wasting in order to provide valuable information for clinical investigation. Recent findings Muscle wasting increases the risk of morbidity/mortality in primary muscle diseases, secondary muscle disorders and elderly population. Muscle mass is controlled by several different signalling pathways. Insulin-like growth factor/PI3K/Akt is a positive signalling pathway, as it increases muscle mass by increasing protein synthesis and decreasing protein degradation. This pathway is directly and/or indirectly downregulated by miR-1, miR-133, miR-206 or miR-125b, and upregulated by miR-23a or miR-486. Myostatin and the transforming growth factor-β signalling pathway are negative regulators that cause muscle wasting. An increase of miR-27 reduces myostatin and increases muscle cell proliferation. Muscle regeneration capacity also plays a significant role in the regulation of muscle mass. This review comprehensively describes the effect of microRNA on myoblasts proliferation and differentiation, and summarizes the varied influences of microRNA on different muscle atrophy. Summary Growing evidence indicates that microRNAs significantly impact muscle growth, regeneration and metabolism. MicroRNAs have a great potential to become diagnostic and/or prognostic markers, therapeutic agents and therapeutic targets.