Noninvasive Imaging to Evaluate Women With Stable Ischemic Heart Disease

• Type of Material: Article
• Authors: Lauren A. Baldassarre, Yale University; Subha V. Raman, Ohio State University; James K. Min, Weill Cornell Medical College; Jennifer H. Mieres, Hofstra Northshore–LIJ School of Medicine; Martha Gulati, University of Arizona; Nanette Wenger, Emory University; Thomas H. Marwick, Menzies Research Institute; Chiara Bucciarelli-Ducci, University of Bristol; C. Noel Bairey Merz, Cedars-Sinai Medical Center; Dipti Itchhaporia, Hoag Memorial Hospital Presbyterian Hospital; Keith C. Ferdinand, Tulane University; Carl J. Pepine, University of Florida; Mary Norine Walsh, St. Vincent Heart Center; Jagat Narula, Icahn School of Medicine at Mount Sinai; Leslee Shaw, Emory University
• Language: English
• Date: 2016-04-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2016 American College of Cardiology Foundation.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jcmg.2016.01.004
• Title of Journal or Parent Work: JACC: Cardiovascular Imaging
• ISSN: 1936-878X
• Volume: 9
• Issue: 4
• Start Page: 421
• End Page: 435
• Grant/Funding Information: Dr. Min is a consultant for HeartFlow; is on the Scientific Advisory Board of Arineta; has ownership of MDDX and Autoplak; has a research agreement with GE Healthcare; and is the recipient of grants NIH/NIHLBI R01HL111141, NIH/NIHLBI R01HL115150, NIH/NIHLBI R01HL118019, NIH/NIHLBI U01HL105907, and NPRP09-370-3-089.; Dr. Bairey Merz has received grant support from Gilead, Practive Point, and Medscape.; Dr. Pepine received grant UL1TR001427 from the National Center for Advancing Translational Sciences.; Dr. Shaw has received the Dean’s Distinguished Faculty Award and the Albert E. Levy Scientific Research Award from Emory University; and has received grant support from the Woodruff Foundation and the Antinori Foundation, and grants NIH-NHLBI R01HL118019-02, R01HL111150, and 1U01HL10556-01; and is a past president of the American Society of Nuclear Cardiology and President-Elect of the Society of Cardiovascular Computed Tomography.
• Keywords: women; OPTICAL COHERENCE TOMOGRAPHY; CORONARY-ARTERY-DISEASE; Cardiac & Cardiovascular Systems; CARDIOVASCULAR MAGNETIC-RESONANCE; POSITRON-EMISSION-TOMOGRAPHY; Radiology, Nuclear Medicine & Medical Imaging; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; prognosis; INTERNATIONAL MULTICENTER CONFIRM; Life Sciences & Biomedicine; INTRAVASCULAR ULTRASOUND ANALYSIS; SYNDROME EVALUATION WISE; MYOCARDIAL-PERFUSION SPECT; Science & Technology; imaging; GENDER-RELATED DIFFERENCES; Cardiovascular System & Cardiology; sex
• Research Categories: Health Sciences, Radiology; Health Sciences, Medicine and Surgery

Abstract

Declines in cardiovascular deaths have been dramatic for men but occur significantly less in women. Among patients with symptomatic ischemic heart disease (IHD), women experience relatively worse outcomes compared with their male counterparts. Evidence to date has failed to adequately explore unique female imaging targets and their correlative signs and symptoms of IHD as major determinants of IHD risk. We highlight sex-specific anatomic and functional differences in contemporary imaging and introduce imaging approaches that leverage refined targets that may improve IHD risk prediction and identify potential therapeutic strategies for symptomatic women.