Anterior Skull Base Reconstruction: Does Fat Preparation Matter?

• Type of Material: Article
• Authors: Joshua Wood, University of Tennessee; Jaron Densky, Ohio State University; John Boughter, University of Tennessee; Courtney Shires, University of Tennessee; Merry Sebelik, Emory University
• Language: English
• Date: 2018-04
• Publisher: Thieme Open
• Publication Version: Final Published Version
• Copyright Statement: © 2018, Rights Managed by Georg Thieme Verlag KG Stuttgart • New York
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1055/s-0038-1645886
• Title of Journal or Parent Work: Journal of Neurological Surgery Reports
• ISSN: 2193-6366
• Volume: 79
• Issue: 02
• Start Page: e31
• End Page: e35
• Keywords: cerebrospinal fluid leak; anterior skull base; autologous fat graft; skull base reconstruction
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, General

Abstract

Objectives  This article aims (1) to determine whether there is any difference in cerebrospinal fluid (CSF) leak rate after anterior skull base autologous fat reconstruction based on how the fat is prepared, and (2) to measure impact on surgical times by reconstruction type. Design  Translational animal model surgical technique 3-arm trial, comparing two different methods of autologous fat skull base reconstruction versus a nonreconstructed control group. Setting  Animal study. Subjects  Adult Sprague-Dawley rats. Main Outcome Measures  Resolution of CSF rhinorrhea after repair of a surgically created anterior skull base defect. Results  Both wet (uncompressed) and dry (compressed) fat reconstruction of an anterior skull base defect demonstrated lower CSF leak rates than nonreconstructed defects. Dry fat reconstruction achieved significance in superiority of controlling CSF leak over no reconstruction (64% success vs. 31%); while wet fat reconstruction trended toward significance (50% vs. 31%). Reconstruction procedure time was longer than nonreconstructed controls, but there was no significant difference between type of fat preparation in surgical time. Conclusions  This study demonstrates that drying and compressing the fat graft improves autologous fat reconstruction success for anterior skull base defects, and does not add significantly to surgical time over nonprepared fat.