Inflammatory and Comorbid Features of Children Admitted to a PICU for Status Asthmaticus*

• Type of Material: Article
• Authors: Jocelyn Rebecca Grunwell, Emory University; Curtis Travers, Emory University; Anne M Fitzpatrick, Emory University
• Language: English
• Date: 2018-11-01
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Copyright © 2018 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
• Final Published Version (URL): http://dx.doi.org/10.1097/PCC.0000000000001695
• Title of Journal or Parent Work: Pediatric Critical Care Medicine
• ISSN: 1529-7535
• Volume: 19
• Issue: 11
• Start Page: E585
• End Page: E594
• Grant/Funding Information: This work was supported in part by R01 NR013700; the National Center for Advancing Translational Sciences of the National Institutes of Health (award no. UL1 TR000454) to Dr. Anne Fitzpatrick; and the Atlanta Pediatric Scholars Program grant K12 HD072245 to Dr. Jocelyn Grunwell.
• Keywords: GUIDELINES; Life Sciences & Biomedicine; General & Internal Medicine; endotracheal intubation; LUNG; asthma; NEAR-FATAL ASTHMA; pneumonia; Pediatrics; Critical Care Medicine; Science & Technology; CRITICAL-CARE; HETEROGENEITY; PHENOTYPES; PATHOGENESIS; NATIONAL HEART; pediatric intensive care unit
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Objectives: To determine risk factors associated with admission to a PICU with or without endotracheal intubation for an asthma exacerbation. We hypothesized that children with critical and near-fatal asthma would have distinguishing clinical features but varying degrees of asthma severity and measures of type 2 inflammation. Design: Retrospective analysis of prospectively collected data of children with asthma recruited into outpatient asthma clinical research studies at Emory University between 2004 and 2015. Setting: Large, free-standing academic quaternary care children’s hospital in Atlanta, GA. Patients: Children 6–18 years old with physician-diagnosed and confirmed asthma. Interventions: None. Measurements and Main Results: A total of 579 children were analyzed with 170 children (29.4%) being admitted to the PICU for an asthma exacerbation in their lifetime. Of these 170 children with a history of critical asthma, 24.1% were classified as having mild-to-moderate asthma, and 83 of 170 children (48.8%) had been intubated and experienced near-fatal asthma. Multiple logistic regression was used to identify risk factors associated with increased odds of PICU admission with or without endotracheal intubation. Hospitalization within the prior 12 months of survey (odds ratio, 8.19; 95% CI, 4.83–13.89), a history of pneumonia (odds ratio, 2.56; 95% CI, 1.52–4.29), having a designation of increased chronic asthma severity on high-dose inhaled corticosteroids (odds ratio, 2.76; 95% CI, 1.62–4.70), having a father with asthma (odds ratio, 2.15; 95% CI, 1.23–3.76), living in a region with a higher burden of poverty (odds ratio, 1.28; 95% CI, 1.02–1.61), and being of black race (odds ratio, 2.01; 95% CI, 1.05–3.84) were all associated with increased odds of PICU admission with or without intubation. Conclusions: Our findings suggest that there are factors associated with critical and near-fatal asthma, distinct from the chronic asthma severity designations, that should be the focus of future investigation. (Pediatr Crit Care Med 2018; 19:e585–e594)