Are brain MRI abnormalities associated with the semiology of functional seizures?

• Type of Material: Article
• Authors: Ali A Asadi-Pooya, Shiraz University of Medical Science; Wesley T Kerr, University of Michigan; Ioannis Karakis, Emory University; Kousuke Kanemoto, Aichi Medical University; Anilu Daza-Restrepo, ENyS CONICET – Neuroscience and Epilepsy Service, El Cruce Hospital “Dr. Néstor Kirchner, ”, Buenos Aires Argentina; Mohsen Farazdaghi, Shiraz University of Medical Science; Faith J Horbatch, University of Michigan, Ann Arbor; Nicholas J Beimer, University of Michigan, Ann Arbor; Dawn E Eliashiv, University of California Los Angeles; Aida Risman, Emory University; Yuko Sugimoto, Aichi Medical University; Brenda Giagante, ENyS CONICET – Neuroscience and Epilepsy Service, El Cruce Hospital “Dr. Néstor Kirchner, ”, Buenos Aires Argentina
• Language: English
• Date: 2023-01-09
• Publisher: WILEY
• Publication Version: Final Published Version
• Copyright Statement: © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/brb3.2882
• Title of Journal or Parent Work: BRAIN AND BEHAVIOR
• Volume: 13
• Issue: 2
• Start Page: e2882
• End Page: e2882
• Keywords: magnetic resonance imaging (MRI); PSYCHOGENIC NONEPILEPTIC SEIZURES; Neurosciences & Neurology; neuropsychiatrics; Science & Technology; Behavioral Sciences; psychiatric disorders; Neurosciences; Life Sciences & Biomedicine
• Research Categories: Biology, Neuroscience

Abstract

Purpose: To investigate whether radiologically apparent brain magnetic resonance imaging (MRI) abnormalities are associated with the functional seizure (FS) semiology. Methods: All patients with a diagnosis of FS at the epilepsy centers at Shiraz University of Medical Sciences, Iran; Aichi Medical University Hospital, Japan; University of Michigan, USA; University of California, Los Angeles, USA; Emory University School of Medicine, USA; and Hospital el Cruce, Argentina, were studied. Results: One hundred patients were included; 77 (77%) had motor functional seizures. Lobar location of brain abnormality did not have an association with the semiology (p =.83). There was no significant difference between ictal behaviors in patients with frontal or parietal lesions compared to those with temporal or occipital lesions. Conclusion: There were no associations between functional seizure ictal behaviors and locations of the radiologically apparent brain MRI abnormalities. Further studies are needed to evaluate the underpinnings of varying behaviors in FS.