Stability of mismatch negativity event-related potentials in a multisite study

• Type of Material: Article
• Authors: Brian J. Roach, San Francisco Veterans Affairs Healthcare System; Holly K. Hamilton, San Francisco Veterans Affairs Healthcare System; Peter Bachman, University of Pittsburgh; Aysenil Belger, University of North Carolina; Ricardo E. Carrion, Zucker Hillside Hospital; Erica Duncan, Emory University; Jason Johannesen, Yale University; Joshua G. Kenney, Yale University; Gregory Light, University of California San Diego; Margaret Niznikiewicz, Harvard Medical School; Jean Addington, University of Calgary; Carrie E. Bearden, University of California Los Angeles; Emily M. Owens, University of California Los Angeles; Kristin S. Cadenhead, University of California San Diego; Tyrone D. Cannon, Yale University; Barbara A. Cornblatt, Zucker Hillside Hospital; Thomas H. McGlashan, Yale University; Diana O. Perkins, University of North Carolina; Larry Seidman, Harvard Medical School; Ming Tsuang, University of California San Diego; Elaine Walker, Emory University; Scott W. Woods, Yale University; Daniel H. Mathalon, San Francisco Veterans Affairs Healthcare System
• Language: English
• Date: 2020-03-30
• Publisher: Wiley
• Publication Version: Final Published Version
• Copyright Statement: © 2020 The Authors. International Journal of Methods in Psychiatric Research Published by John Wiley & Sons Ltd.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/mpr.1819
• Title of Journal or Parent Work: International Journal of Methods in Psychiatric Research
• Volume: 29
• Issue: 2
• Start Page: e1819
• End Page: e1819
• Grant/Funding Information: This work was supported by grants from National Institute of Mental Health (U01MH081902 to TDC, P50 MH066286 to CEB, U01MH081988 to EFW, U01MH076989 to DHM, U01MH081944 to KSC, U01MH081984 to JA, U01MH082004 to DOP, U01MH081857 to BAC, U01MH081928 to LJS, U01MH082022 to SW).
• Keywords: generalizability; Schizophrenia; Psychiatry; Clinical high risk; Duration; Global assessment; Science & Technology; stability; Frequency; Test-retest reliability; Attentive change detection; event-related potential (ERP); Psychosis risk; Volume loss; Life Sciences & Biomedicine; standardization; mismatch negativity (MMN); Metaanalysis
• Research Categories: Psychology, Experimental; Biology, Neuroscience; Psychology, Psychobiology; Psychology, Behavioral

Abstract

Objectives Mismatch negativity (MMN), an auditory event‐related potential sensitive to deviance detection, is smaller in schizophrenia and psychosis risk. In a multisite study, a regression approach to account for effects of site and age (12–35 years) was evaluated alongside the one‐year stability of MMN. Methods Stability of frequency, duration, and frequency + duration (double) deviant MMN was assessed in 167 healthy subjects, tested on two occasions, separated by 52 weeks, at one of eight sites. Linear regression models predicting MMN with age and site were validated and used to derive standardized MMN z‐scores. Variance components estimated for MMN amplitude and latency measures were used to calculate Generalizability (G) coefficients within each site to assess MMN stability. Trait‐like aspects of MMN were captured by averaging across occasions and correlated with subject traits. Results Age and site accounted for less than 7% of MMN variance. G‐coefficients calculated at electrode Fz were stable (G = 0.63) across deviants and sites for amplitude measured in a fixed window, but not for latency (G = 0.37). Frequency deviant MMN z‐scores averaged across tests negatively correlated with averaged global assessment of functioning. Conclusion MMN amplitude is stable and can be standardized to facilitate longitudinal multisite studies of patients and clinical features.