The Impact of Cocaine Use and the Obesity Paradox in Patients With Heart Failure With Reduced Ejection Fraction Due to Non-ischemic Cardiomyopathy.

• Type of Material: Article
• Authors: Adedoyin A Akinlonu, Emory University; Alvaro Alonso, Emory University; Tuoyo O Mene-Afejuku, Emory University; Persio Lopez, New York Medical College, Metropolitan Hospital Center; Tikal Kansara, New York Medical College, Metropolitan Hospital Center; Olatunde Ola, Mayo Clinic Health System, La Crosse; Savi Mushiyev, New York Medical College, Metropolitan Hospital Center; Gerald Pekler, New York Medical College, Metropolitan Hospital Center
• Language: English
• Date: 2023-06
• Publisher: SPRINGER NATURE
• Publication Version: Final Published Version
• Copyright Statement: © 2023, Akinlonu et al.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.7759/cureus.40298
• Title of Journal or Parent Work: Cureus
• Volume: 15
• Issue: 6
• Start Page: e40298
• End Page: e40298
• Grant/Funding Information: Alvaro Alonso declare(s) a grant from National Institutes of Health. Dr. Alonso was supported by NIH/NHLBI grant K24HL148521 outside of this submitted work.
• Keywords: heart failure outcomes; obesity paradox; cocaine use; non-ischemic cardiomyopathy; hospital readmission
• Research Categories: Health Sciences, Epidemiology; Health Sciences, Public Health; Engineering, Biomedical; Health Sciences, Medicine and Surgery

Abstract

Background Obesity and illicit drugs are independent risk factors for developing heart failure (HF). However, recent studies have suggested that patients who already have HF and are obese have better clinical outcomes. We aim to study the effect of cocaine use on this obesity paradox phenomenon as it pertains to HF readmissions. Methodology In a retrospective chart analysis, we reviewed patients with a diagnosis of HF with reduced ejection fraction (HFrEF) admitted to Metropolitan Hospital in New York. We studied the association between body mass index (BMI) categories, namely, non-obese (<30 kg/m2) and obese (≥30 kg/m2), cocaine use, and the primary outcome (time to readmission for HF within 30 days after discharge). The interaction between cocaine and obesity status and its association with the primary outcome was also assessed. Results A total of 261 patients were identified. Non-obese status and cocaine use were associated with an increased hazard of readmission in 30 days (hazard ratio (HR) = 2.28, p = 0.049 and HR = 3.12, p = 0.004, respectively). Furthermore, cocaine users who were non-obese were over six times more likely to be re-admitted in 30 days compared to non-cocaine users who were obese (HR = 6.45, p = 0.0002). Conclusions Non-obese status and continued use of cocaine have a negative additive effect in impacting HF readmissions.