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Measurement and Finite element Model Validation of immature Porcine Brain-skull Displacement during rapid sagittal head rotations

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Last modified
  • 06/25/2025
Type of Material
Authors
    Stephanie A. Pasquesi, University of PennsylvaniaSusan Margulies, Emory University
Language
  • English
Date
  • 2018-02-21
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2018 Pasquesi and Margulies.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 2296-4185
Volume
  • 6
Issue
  • FEB
Start Page
  • 16
End Page
  • 16
Grant/Funding Information
  • This study was sponsored by the American Heart Association (12PRE12040315) and the National Institutes of Health (R21 HD078842 and R01 NS039679).
Abstract
  • Computational models are valuable tools for studying tissue-level mechanisms of traumatic brain injury, but to produce more accurate estimates of tissue deformation, these models must be validated against experimental data. In this study, we present in situ measurements of brain-skull displacement in the neonatal piglet head (n = 3) at the sagittal midline during six rapid non-impact rotations (two rotations per specimen) with peak angular velocities averaging 51.7 ± 1.4 rad/s. Marks on the sagittally cut brain and skull/rigid potting surfaces were tracked, and peak values of relative brain-skull displacement were extracted and found to be significantly less than values extracted from a previous axial plane model. In a finite element model of the sagittally transected neonatal porcine head, the brain-skull boundary condition was matched to the measured physical experiment data. Despite smaller sagittal plane displacements at the brain-skull boundary, the corresponding finite element boundary condition optimized for sagittal plane rotations is far less stiffthan its axial counterpart, likely due to the prominent role of the boundary geometry in restricting interface movement. Finally, bridging veins were included in the finite element model. Varying the bridging vein mechanical behavior over a previously reported range had no influence on the brain-skull boundary displacements. This direction-specific sagittal plane boundary condition can be employed in finite element models of rapid sagittal head rotations.
Author Notes
Keywords
Research Categories
  • Engineering, Biomedical
  • Biology, Anatomy

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