Blood Pressure Indexes and End-Stage Renal Disease Risk in Adults With Chronic Kidney Disease

• Type of Material: Article
• Authors: Emmy K. Bell, University of Alabama at Birmingham; Liyan Gao, University of Alabama at Birmingham; Suzanne Judd, University of Alabama at Birmingham; Stephen P. Glasser, University of Alabama at Birmingham; William McClellan, Emory University; Orlando M. Gutiérrez, University of Alabama at Birmingham; Monika Safford, University of Alabama at Birmingham; Daniel T. Lackland, Medical University of South Carolina; David G. Warnock, University of Alabama at Birmingham; Paul Muntner, University of Alabama at Birmingham
• Language: English
• Date: 2012-07-01
• Publisher: Oxford University Press (OUP): Policy B - Oxford Open Option D
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 American Journal of Hypertension, Ltd.
• Final Published Version (URL): http://dx.doi.org/10.1038/ajh.2012.48
• Title of Journal or Parent Work: American Journal of Hypertension
• ISSN: 0895-7061
• Volume: 25
• Issue: 7
• Start Page: 789
• End Page: 796
• Grant/Funding Information: Additional funding was provided by an investigator-initiated grant-in-aid from Amgen Corporation to D.G.W.; This research project is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service.
• Keywords: End-Stage Renal Disease; Chronic Kidney Disease; Blood Pressure; Systolic Blood Pressure; Hypertension; Pulse Pressure
• Research Categories: Health Sciences, Epidemiology; Biology, Biostatistics; Biology, Neuroscience

Abstract

Few studies have compared different blood pressure (BP) indexes for end-stage renal disease (ESRD) risk among individuals with chronic kidney disease.We examined the relationship between systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP) and mean arterial pressure (MAP) and ESRD risk among 2,772 participants with an estimated glomerular filtration rate (eGFR) <60ml/min/1.73 m2 calculated using the Chronic Kidney Disease Epidemiology Collaboration equation in the REasons for the Geographic And Racial Differences in Stroke (REGARDS) study. BP was measured during a baseline study visit between January 2003 and October 2007 with ESRD incidence through August 2009 ascertained via linkage with the United States Renal Data System (n = 138 ESRD cases).