Oxidative balance score and risk for incident prostate cancer in a prospective US cohort study

• Type of Material: Article
• Authors: Sindhu Lakkur, Emory University; Michael Goodman, Emory University; Roberd M Bostick, Emory University; Jessica Citronberg, Emory University; William McClellan, Emory University; W Dana Flanders, Emory University; Suzanne Judd, University of Alabama Birmingham; Victoria Stevens, Emory University
• Language: English
• Date: 2014-06-01
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2014 Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.annepidem.2014.02.015
• Title of Journal or Parent Work: Annals of Epidemiology
• ISSN: 1047-2797
• Volume: 24
• Issue: 6
• Start Page: 475
• End Page: 478
• Keywords: Science & Technology; STRESS; FREE-RADICALS; POLYUNSATURATED FATTY-ACIDS; Prostatic neoplasms; NUTRITION; Cohort study; OBESITY; PREVENTION; Public, Environmental & Occupational Health; Oxidative stress; Life Sciences & Biomedicine; INFLAMMATION; N-3; ANTIOXIDANT EXPOSURES
• Research Categories: Health Sciences, Nutrition; Health Sciences, Oncology; Health Sciences, Epidemiology

Abstract

Purpose: Oxidative stress is defined as an imbalance between pro-oxidants and antioxidants. Previous research found that a single comprehensive oxidative balance score (OBS) that includes individual pro- and anti-oxidant exposures may be associated with various conditions (including prostate cancer) in the absence of associations with the individual factors. We investigated an OBS-incident prostate cancer association among 43,325 men in the Cancer Prevention Study II Nutrition Cohort. Methods: From 1999-2007, 3386 incident cases were identified. Twenty different components, used in two ways (unweighted or weighted based on literature reviews), were incorporated into the OBS, and the resulting scores were then expressed as three types of variables (continuous, quartiles, or six equal intervals). Multivariable-adjusted rate ratios were calculated using Cox proportional hazards models. Results: We hypothesized that the OBS would be inversely associated with prostate cancer risk; however, the rate ratios (95% confidence intervals) comparing the highest with the lowest OBS categories ranged from 1.17 (1.04-1.32) to 1.39 (0.90-2.15) for all cases, 1.14 (0.87-1.50) to 1.59 (0.57-4.40) for aggressive disease (American Joint Committee on Cancer stage III/IV or Gleason score 8-10), and 0.91 (0.62-1.35) to 1.02 (1.02-1.04) for nonaggressive disease. Conclusions: Our findings are not consistent with the hypothesis that oxidative balance-related exposures collectively affect risk for prostate cancer.