Sleep problems and attenuated psychotic symptoms in youth at clinical high-risk for psychosis

• Type of Material: Article
• Authors: Katrina Goines, Emory University; Allison LoPilato, Emory University; Jean Addington, University of Calgary; CE Bearden, University of California Los Angeles; KS Cadenhead, University of California San Diego; TD Cannon, Yale University; BA Cornblatt, Zucker Hillside Hospital; DH Mathalon, University of California San Francisco; TH McGlashan, Yale University; DO Perkins, University of North Carolina; Ming T Tsuang, University of California San Diego; Scott W. Woods, Yale University; Elaine Walker, Emory University
• Language: English
• Date: 2019-12-01
• Publisher: ELSEVIER IRELAND LTD
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: 2019
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.psychres.2019.112492
• Title of Journal or Parent Work: PSYCHIATRY RESEARCH
• Volume: 282
• Start Page: 112492
• End Page: 112492
• Grant/Funding Information: This work was supported by a collaborative U01 award from the National Institute of Mental Health at the National Institutes of Health (MH081902 to TDC and CB; MH081857 to BAC; MH081988 to EW; MH081928 to LS; MH082004 to DP; MH081944 to KC; MH081984 to JA; MH082022 to SWW; and MH076989)
• Keywords: Prodromal; Schizophrenia-spectrum; HALLUCINATIONS; Psychiatry; Life Sciences & Biomedicine; CHR; ULTRA-HIGH-RISK; Prodrome; ADOLESCENTS; PERSISTENCE; Science & Technology; SCHIZOPHRENIA; YOUNG-PEOPLE; Insomnia; PRODROME; DEPRESSION; DISTURBANCES; MODEL
• Research Categories: Engineering, Biomedical

Abstract

There has been growing interest on the effect of sleep problems on psychotic and prodromal symptoms. The current study investigated cross-sectional relations between sleep problems and attenuated psychotic symptoms in a large sample of 740 youth at Clinical High Risk (CHR) for psychosis in an attempt to replicate previous findings and assess whether findings from general population samples and psychotic samples extend to this CHR sample. Sleep problems were found to be significantly positively associated with attenuated psychotic symptom severity. Sleep problems were also found to be more closely associated with certain specific prodromal symptoms (e.g., suspiciousness and perceptual abnormalities) than other attenuated psychotic symptoms. Further, we found that depression mediated the cross-sectional association between sleep problems and paranoid symptoms only. This adds to a growing body of evidence suggesting the mediation role of depression is more pronounced for paranoid-type psychotic symptoms as compared to other psychotic symptoms (e.g., hallucinations).