Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study

• Type of Material: Article
• Authors: Baris Gencer, Geneva University Hospital; Reto Auer, Lausanne University Hospital; Nathalie de Rekeneire, Yale University; Javed Butler, Emory University; Andreas Kalogeropoulos, Emory University; Douglas C. Bauer, University of California, San Francisco; Stephen B. Kritchevsky, Wake Forrest School of Medicine; Iva Miljkovic, University of Pittsburgh; Eric Vittinghoff, University of California, San Francisco; Tamara Harris, National Institute on Aging; Nicolas Rodondi, University of Bern
• Language: English
• Date: 2016-02-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 Elsevier Ireland Ltd.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.atherosclerosis.2015.12.004
• Title of Journal or Parent Work: Atherosclerosis
• ISSN: 0021-9150
• Volume: 245
• Start Page: 181
• End Page: 186
• Grant/Funding Information: This research was supported in part by the Intramural Research Program of the National Institutes of Health (NIH). National Institute on Aging (NIA), Bethesda Md.; Prof Rodondi’s research is supported by a grant from the Swiss National Science Foundation (SNSF 320030-150025) and the Swiss Heart Foundation.; This research was supported by NIA Contracts N01-AG-6-2101; N01-AG-6-2103; N01-AG-6-2106; NIA grant R01-AG028050, and NINR grant R01-NR01259.; Dr Gencer’s research on cardiovascular prevention is supported by a grant from the Swiss National Science Foundation (SNSF SPUM33CM30-140336, Inflammation and acute coronary syndromes (ACS) – Novel strategies for prevention and clinical management), Swiss Heart Foundation, Geneva University Hospitals, Foundation Schmidheiny, Foundation Gerbex-Bourget and De Reuter Foundation.
• Keywords: Cohort studies; Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; INFLAMMATION; CORONARY-HEART-DISEASE; ARTERY-DISEASE; OBESITY; RISK; EXPRESSION; FAILURE; Biomarkers; Peripheral Vascular Disease; Inflammation; Insulin resistance; Science & Technology; Cardiovascular prevention; Life Sciences & Biomedicine; ATHEROSCLEROSIS; INSULIN-RESISTANCE; HUMANS
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, Epidemiology

Abstract

Objective: Prospective data on the association between resistin levels and cardiovascular disease (CVD) events are sparse with conflicting results. Methods: We studied 3044 aged 70-79 years from the Health, Aging, and Body Composition Study. CVD events were defined as coronary heart disease (CHD) or stroke events. «Hard » CHD events were defined as CHD death or myocardial infarction. We estimated hazard ratio (HR) and 95% confidence intervals (CI) according to the quartiles of serum resistin concentrations and adjusted for clinical variables, and then further adjusted for metabolic disease (body mass index, fasting plasma glucose, abdominal visceral and subcutaneous adipose tissue, leptin, adiponectin, insulin) and inflammation (C-reactive protein, interleukin-6, tumor necrosis factors-α). Results: During a median follow-up of 10.1 years, 559 patients had « hard » CHD events, 884 CHD events and 1106 CVD Events. Unadjusted incidence rate for CVD events was 36.6 (95% CI 32.1-41.1) per 1000 persons-year in the lowest quartile and 54.0 per 1000 persons-year in the highest quartile (95% CI 48.2-59.8, P for trend < 0.001). In the multivariate models adjusted for clinical variables, HRs for the highest vs. lowest quartile of resistin was 1.52 (95% CI 1.20-1.93, P < 0.001) for « Hard » CHD events, 1.41 (95% CI 1.16-1.70, P = 0.001) for CHD events and 1.35 (95% CI 1.14-1.59, P = 0.002) for CVD events. Further adjustment for metabolic disease slightly reduced the associations while adjustment for inflammation markedly reduced the associations. Conclusions: In older adults, higher resistin levels are associated with CVD events independently of clinical risk factors and metabolic disease markers, but markedly attenuated by inflammation.