Spectrum of CD30+ Lymphoid Proliferations in the Eyelid: Lymphomatoid Papulosis, Cutaneous Anaplastic Large Cell Lymphoma, and Anaplastic Large Cell Lymphoma

• Type of Material: Article
• Authors: R. Krishna Sanka, Emory University; Ralph C. Eagle, Wills Eye Institute; Ted H Wojno, Emory University; Kenneth R. Neufeld, Thomas Eye Group; Hans Grossniklaus, Emory University
• Language: English
• Date: 2010-02
• Publisher: Springer Verlag (Germany)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.ophtha.2009.07.013
• Title of Journal or Parent Work: Ophthalmologe
• ISSN: 0941-293X
• Volume: 117
• Issue: 2
• Start Page: 343
• End Page: 351
• Grant/Funding Information: Dr. Grossniklaus is a recipient of the Research to Prevent Blindness Senior Scientific Investigator Award.; Supported in part by an unrestricted department grant from Research to Prevent Blindness, Inc., and NIH P30 EY06360.
• Research Categories: Health Sciences, Pathology; Health Sciences, Opthamology

Abstract

Purpose: To report the clinicopathologic features of three patients with CD30+ lymphoid proliferations of the eyelid. Design: Retrospective case series. Participants: Patients with cutaneous CD30+ lymphoproliferative lesions of the eyelid. Methods: Three patients with CD30+ non-mycosis fungoides T cell lymphoid infiltrates of the eyelid were identified. The histories, clinical findings, pathologic features including immunohistochemical staining, treatments and outcomes were reviewed and compared. Main Outcome Measures: Pathologic findings including immunohistochemical analysis. Results: The patients included an 81-year-old man, an 18-year-old man, and a 42-year-old woman, with CD30+ lymphoid proliferations of the eyelid and adjacent soft tissue. The first patient had an isolated crateriform eyelid lesion that was classified as lymphomatoid papulosis (LyP). The second patient had an isolated multinodular lesion of the eyelid that was classified as cutaneous anaplastic large cell lymphoma (cALCL). The third patient presented with eyelid edema with an underlying mass and was found to have widely disseminated anaplastic large cell lymphoma (ALCL). Diagnoses were dependent on clinical findings. Conclusions: CD30+ lymphoid proliferations represent a spectrum of conditions ranging from indolent LyP, to moderately aggressive cALCL, and to highly aggressive ALCL. Interpretation of the pathologic findings in CD30+ lymphoid proliferations is based in part on clinical findings.