Immunology of Mycobacterium tuberculosis Infections

• Type of Material: Article
• Authors: Jonathan Kevin Sia, Emory University; Jyothi Rengarajan, Emory University
• Language: English
• Date: 2019-07-01
• Publisher: American Society for Microbiology
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 American Society for Microbiology.
• Final Published Version (URL): http://dx.doi.org/10.1128/microbiolspec.GPP3-0022-2018
• Title of Journal or Parent Work: Microbiology Spectrum
• ISSN: 2165-0497
• Volume: 7
• Issue: 4
• Keywords: T-CELL RESPONSES; INTERFERON-GAMMA-RECEPTOR; INHERITED INTERLEUKIN-12 DEFICIENCY; CYTOSOLIC SURVEILLANCE PATHWAY; ACTIVE PULMONARY TUBERCULOSIS; ADAPTIVE IMMUNE-RESPONSE; Microbiology; LONG-TERM CONTROL; Science & Technology; BACILLE CALMETTE-GUERIN; Life Sciences & Biomedicine; IMMUNODEFICIENCY-VIRUS TYPE-1; NITRIC-OXIDE SYNTHASE
• Research Categories: Health Sciences, Immunology; Biology, Microbiology; Health Sciences, Medicine and Surgery

Abstract

Tuberculosis (TB) is a serious global public health challenge that results in significant morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium tuberculosis (M. tuberculosis), which has evolved a wide variety of strategies in order to thrive within its host. Understanding the complex interactions between M. tuberculosis and host immunity can inform the rational design of better TB vaccines and therapeutics. This chapter covers innate and adaptive immunity against M. tuberculosis infection, including insights on bacterial immune evasion and subversion garnered from animal models of infection and human studies. In addition, this chapter discusses the immunology of the TB granuloma, TB diagnostics, and TB comorbidities. Finally, this chapter provides a broad overview of the current TB vaccine pipeline.