The three-dimensional cancer genome

• Type of Material: Article
• Authors: M. Ryan Corces, Stanford University; Victor Corces, Emory University
• Language: English
• Date: 2016-02
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2016 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.gde.2016.01.002
• Title of Journal or Parent Work: Current Opinion in Genetics and Development
• ISSN: 0959-437X
• Volume: 36
• Start Page: 1
• End Page: 7
• Grant/Funding Information: V.G.C. acknowledges support from U.S. Public Health Service Award R01GM035463 from the National Institutes of Health.; M.R.C. acknowledges funding from the National Institutes of Health training grant R25CA180993.
• Keywords: Chromatin; Cohesin; Epigenetics; Cancer; 3D architecture; CTCF
• Research Categories: Health Sciences, Oncology; Biology, Genetics

Abstract

The past decade of cancer research has ushered in a comprehensive understanding of the way that the sequence of the genome can be coopted during the process of tumorigenesis. However, only recently has the epigenome, and in particular the three-dimensional topology of chromatin, been implicated in cancer progression. Here we review recent findings of how the cancer genome is regulated and dysregulated to effect changes in 3D genome topology. We discuss the impact of the spatial organization of the genome on the frequency of tumorigenic chromosomal translocations and the effects of disruption of the proteins responsible for the establishment of chromatin loops. Alteration of the three-dimensional cancer genome is a rapidly emerging hallmark of multiple cancer subtypes.