Publication

Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity

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Last modified
  • 05/14/2025
Type of Material
Authors
    Thayer K. Darling, Emory UniversityTracey Lamb, Emory University
Language
  • English
Date
  • 2019-07-04
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • Copyright © 2019 Darling and Lamb.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-3224
Volume
  • 10
Issue
  • JULY
Start Page
  • 1473
End Page
  • 1473
Grant/Funding Information
  • This work was supported by grants from the National Institute for Neurological Disorders and Stroke to TD (F31NS098736); and to TL (R21NS085382 and R01NS097819); along with training grants T32AI007610 and T32AI106699 to TD.
Abstract
  • Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands. The ubiquitous expression of Eph receptors and ephrin ligands among the cellular players of the immune system underscores the importance of these molecules in orchestrating an optimal immune response. This review provides an overview of the various roles of Eph receptors and ephrin ligands in immune cell development, activation, and migration. We also discuss the role of Eph receptors in disease pathogenesis as well as the implications of Eph receptors as future immunotherapy targets. Given the diverse and critical roles of Eph receptors and ephrin ligands throughout the immune system during both resting and activated states, this review aims to highlight the critical yet underappreciated roles of this family of signaling molecules in the immune system.
Author Notes
Keywords
Research Categories
  • Health Sciences, Pathology
  • Health Sciences, Medicine and Surgery
  • Health Sciences, Immunology

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