Urate Transporter Gene SLC22A12 Polymorphisms Associated with Obesity and Metabolic Syndrome in Caucasians with Hypertension

• Type of Material: Article
• Authors: Mohamed Shafiu, University of Florida; Richard J. Johnson, University of Florida; Stephen T. Turner, Mayo Clinic; Taimour Langaee, University of Florida; Yan Gong, University of Florida; Arlene B Chapman, Emory University; John G. Gums, University of Florida; Julie A. Johnson, University of Florida
• Language: English
• Date: 2012-06-08
• Publisher: Karger Publishers Open Access
• Publication Version: Final Published Version
• Copyright Statement: © 2012 S. Karger AG, Basel.
• Final Published Version (URL): http://dx.doi.org/10.1159/000337370
• Title of Journal or Parent Work: Kidney and Blood Pressure Research
• ISSN: 1420-4096
• Volume: 35
• Issue: 6
• Start Page: 477
• End Page: 482
• Grant/Funding Information: The PEAR study, and this research, is supported by a grant from the National Institutes of Health (Bethesda, Md., USA), grant U01 GM074492, funded as part of the Pharmacogenetics Research Network.; The study was also supported by PEAR CTSA grants UL1-RR092890 (University of Florida), UL1-RR025008 (Emory University), and UL1-RR024150 (Mayo Clinic), and funds from the Mayo Foundation, NIH HL-68607 and an Amgen fellowship grant to Dr. Shafiu.
• Keywords: ALLOPURINOL; Metabolic syndrome; SLC22A12 polymorphisms; Obesity; Physiology; EXCRETION; CELLS; FRUCTOSE; SLC2A9; SERUM URIC-ACID; Peripheral Vascular Disease; CARDIOVASCULAR-DISEASE; Uric acid; HYPERURICEMIA; RISK-FACTORS; Urology & Nephrology; Cardiovascular System & Cardiology; Life Sciences & Biomedicine; Hypertension; URAT1; BLOOD-PRESSURE; Science & Technology
• Research Categories: Health Sciences, Pharmacology; Health Sciences, Pharmacy; Biology, Genetics

Abstract

Background/Aims: Hyperuricemia is associated with obesity and the metabolic syndrome. URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects. Methods: Patients with essential hypertension (n = 414) from a randomized controlled study were genotyped for SLC22A12 SNPs rs11602903, rs505802 and rs11231825. Results: In Caucasians, SLC22A12 SNPs were associated with the body mass index (BMI). rs11602903 was associated with BMI (p < 0.0001), waist circumference (p = 0.003), HDL cholesterol (p = 0.018) and the metabolic syndrome (p = 0.033), and accounted for 7% of the variation of BMI in Caucasians. In African Americans, SLC22A12 SNP rs11602903 was not associated with BMI, waist circumference, HDL cholesterol or triglycerides. Conclusion: The URAT1 gene SLC22A12 polymorphism may play a role in obesity and the metabolic syndrome in Caucasian hypertensive subjects.