Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine

• Type of Material: Article
• Authors: Jeffrey Scott Stehouwer, Emory University; Mark Goodman, Emory University
• Language: English
• Date: 2009-01
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2009 Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.cpet.2009.05.006
• Title of Journal or Parent Work: PET Clinics
• ISSN: 1556-8598
• Volume: 4
• Issue: 1
• Start Page: 101
• End Page: 128
• Keywords: Serotonin Transporter; Fluorine-18 PET; Tropanes; Dopamine Transporter; Norepinephrine Transporter
• Research Categories: Health Sciences, Radiology

Abstract

This review focuses on the development of fluorine-18 radiolabeled PET tracers for imaging the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). All successful DAT PET tracers reported to date are members of the 3β-phenyl tropane class and are synthesized from cocaine. Currently available carbon-11 SERT PET tracers come from both the diphenylsulfide and 3β-phenyl nortropane class, but so far only the nortropanes have found success with fluorine-18 derivatives. NET imaging has so far employed carbon-11 and fluorine-18 derivatives of reboxetine but due to defluorination of the fluorine-18 derivatives further research is still necessary.