The Great Escape: Microbiotal LPS Takes a Toll on the Liver

• Type of Material: Article
• Authors: David S Weiss, Emory University
• Language: English
• Date: 2012-09-01
• Publisher: American Association for Cancer Research
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: ©2012 AACR.
• Final Published Version (URL): http://dx.doi.org/10.1158/1940-6207.CAPR-12-0248
• Title of Journal or Parent Work: Cancer Prevention Research
• ISSN: 1940-6207
• Volume: 5
• Issue: 9
• Start Page: 1078
• End Page: 1080
• Grant/Funding Information: This work was supported by NIH grant U54 AI057157 from SERCEB.
• Keywords: GUT MICROBIOTA; COLITIS; Science & Technology; HUMAN HEALTH; INFLAMMATION; BACTERIAL TRANSLOCATION; CANCER; HEPATITIS; TLR4; Oncology; Life Sciences & Biomedicine
• Research Categories: Biology, Virology; Health Sciences, Immunology; Biology, Microbiology

Abstract

The interaction between the intestinal microbiota and host is much more complex than previously appreciated, and we are now learning that it can have an impact on extraintestinal human diseases. In this issue of the journal (beginning on page 1090), Lin and colleagues present important data linking the microbiota, lipopolysaccharide (LPS), and toll-like receptor (TLR)4 with hepatitis in a mouse model. These provocative results and those from other recent studies highlight the microbiota as a potential target for therapeutic intervention in several liver diseases.