Vaccines against Emerging and Neglected Infectious Diseases: An Overview

• Type of Material: Article
• Authors: Larissa Vuitika, University of São Paulo (ICB-IV/USP); Wasim A Prates-Syed, University of São Paulo (ICB-IV/USP); Jacqueline Dinis Queiros Silva, Federal University of Bahia, Salvador; Karin P Crema, University of São Paulo (ICB-IV/USP); Nelson Côrtes, University of São Paulo (ICB-IV/USP); Aline Lira, University of São Paulo (ICB-IV/USP); Julia Beatriz Menuci Lima, University of São Paulo (ICB-IV/USP); Niels Olsen Saraiva Camara, University of São Paulo (ICB-IV/USP); Lena F Schimke, University of São Paulo (ICB-IV/USP); Otavio Cabral-Marques, University of São Paulo (ICB-IV/USP); Mohammad Sadraeian, University of Technology, Sydney; Lorena CS Chaves, Emory University; Gustavi Cabral-Miranda, University of São Paulo (ICB-IV/USP)
• Language: English
• Date: 2022-09-01
• Publisher: MDPI AG
• Publication Version: Final Published Version
• Copyright Statement: © 2022 by the authors.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3390/vaccines10091385
• Title of Journal or Parent Work: Vaccines
• Volume: 10
• Issue: 9
• Grant/Funding Information: This research group is funded by The São Paulo Research Foundation, FAPESP-Grant 2019/14526-0 and 2020/05146-7.
• Keywords: emerging infectious diseases; neglected diseases; vaccines
• Research Categories: Health Sciences, Immunology

Abstract

Neglected Tropical Diseases (NTDs) are a group of diseases that are highly prevalent in tropical and subtropical regions, and closely associated with poverty and marginalized populations. Infectious diseases affect over 1.6 billion people annually, and vaccines are the best prophylactic tool against them. Along with NTDs, emerging and reemerging infectious diseases also threaten global public health, as they can unpredictably result in pandemics. The recent advances in vaccinology allowed the development and licensing of new vaccine platforms that can target and prevent these diseases. In this work, we discuss the advances in vaccinology and some of the difficulties found in the vaccine development pipeline for selected NTDs and emerging and reemerging infectious diseases, including HIV, Dengue, Ebola, Chagas disease, malaria, leishmaniasis, zika, and chikungunya.