Cardiac Resynchronization Therapy for Adult Patients With a Failing Systemic Right Ventricle: A Multicenter Study

• Type of Material: Article
• Authors: Rohit K Kharbanda, University Medical Center; Jeremy P Moore, Ahmanson UCLA Adult Congenital Heart Dis Ctr; Michael Lloyd, Emory University; Robert Galotti, Ahmanson UCLA Adult Congenital Heart Dis Ctr; Ad JJC Bogers, University Medical Center, Rotterdam; Yannick JHJ Taverne, University Medical Center, Rotterdam; Malini Madhavan, Mayo Clinic; Christopher J McLeod, Mayo Clinic; Anne M Dubin, Stanford University; Douglas Y Mah, Boston Childrens Hospital; Philip M Chang, University of Florida Health; Anna N Kamp, Nationwide Childrens Hospital; Jens C Nielsen, Aarhus University; Alper Aydin, University of Ottawa; Ronn E Tanel, University of California San Francisco; Maully J Shah, Childrens Hospital of Philadelphia; Thomas Pilcher, University of Utah; Reinder Evertz, Radboud University Nijmegen; Paul Khairy, Université de Montréal; Reina B Tan, New York University; Richard J Czosek, Cincinnati Children’s Hospital Medical Center; Kalyanam Shivkumar, Ahmanson UCLA Adult Congenital Heart Dis Ctr; Natasja MS de Groot, University Medical Center, Rotterdam
• Language: English
• Date: 2022-11-15
• Publisher: WILEY
• Publication Version: Final Published Version
• Copyright Statement: © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1161/JAHA.121.025121
• Title of Journal or Parent Work: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• Volume: 11
• Issue: 22
• Start Page: e025121
• End Page: e025121
• Grant/Funding Information: None.
• Keywords: cardiac resynchronization therapy; congenital heart disease; Life Sciences & Biomedicine; Science & Technology; heart failure; Cardiovascular System & Cardiology; systemic right ventricle; pacing; Cardiac & Cardiovascular Systems; CONGENITAL HEART-DISEASE
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

BACKGROUND: The objective of this international multicenter study was to investigate both early and late outcomes of cardiac resynchronization therapy (CRT) in patients with a systemic right ventricle (SRV) and to identify predictors for congestive heart failure readmissions and mortality. METHODS AND RESULTS: This retrospective international multicenter study included 13 centers. The study population comprised 80 adult patients with SRV (48.9% women) with a mean age of 45±14 (range, 18–77) years at initiation of CRT. Median follow-up time was 4.1 (25th–75th percentile, 1.3– 8.3) years. Underlying congenital heart disease consisted of congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries in 63 (78.8%) and 17 (21.3%) patients, respectively. CRT resulted in significant improvement in functional class (before CRT: III, 25th–75th percentile, II– III; after CRT: II, 25th–75th percentile, II– III; P=0.005) and QRS duration (before CRT: 176±27; after CRT: 150±24 milliseconds; P=0.003) in patients with pre-CRT ventricular pacing who underwent an upgrade to a CRT device (n=49). These improvements persisted during long-term follow-up with a marginal but significant increase in SRV function (before CRT; 30%, 25th–75th percentile, 25– 35; after CRT: 31%, 25th–75th percentile, 21– 38; P=0.049). In contrast, no beneficial change in the above-mentioned vari-ables was observed in patients who underwent de novo CRT (n=31). A quarter of all patients were readmitted for heart failure during follow-up, and mortality at latest follow-up was 21.3%. CONCLUSIONS: This international experience with CRT in patients with an SRV demonstrated that CRT in selected patients with SRV dysfunction and pacing-induced dyssynchrony yielded consistent improvement in QRS duration and New York Heart Association functional status, with a marginal increase in SRV function.