Developmental undernutrition, offspring obesity and type 2 diabetes

• Type of Material: Article
• Authors: Aryeh Stein, Emory University; Okezi E Obrutu, Emory University; Rishikesh V Behere, King Edward Memorial Hospital Research Centre; Chittaranjan S Yajnik, King Edward Memorial Hospital Research Centre
• Language: English
• Date: 2019-10-01
• Publisher: SPRINGER
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019, Springer-Verlag GmbH Germany, part of Springer Nature
• Final Published Version (URL): http://dx.doi.org/10.1007/s00125-019-4930-1
• Title of Journal or Parent Work: DIABETOLOGIA
• Volume: 62
• Issue: 10
• Start Page: 1773
• End Page: 1778
• Grant/Funding Information: CSY reports funding from the Department of Biotechnology, Govt of India, New Delhi: BT/PR12629/MED/97/364/2016; the Indian Council of Medical Research & Medical Research Council, UK joint grant under an Indo-UK call: ICMR-MRC-(58/1/8/MRC-ICMR/2009/NCD-II) MRC- (MR/J000094/1); The Wellcome Trust: 034384/Z/91/Z, 038128/Z/93.
• Keywords: Obesity; ETHNIC-DIFFERENCES; GLUCOSE-TOLERANCE; Type 2 diabetes; PREGNANCY; NEONATAL ANTHROPOMETRY; Science & Technology; BIRTH-WEIGHT; Life Sciences & Biomedicine; Endocrinology & Metabolism; PRENATAL EXPOSURE; Undernutrition; EARLY-LIFE; CHINESE FAMINE; IN-UTERO; COHORT PROFILE; Life course development; Review

Abstract

The Developmental Origins of Health and Disease (DOHaD) paradigm posits that a mismatch between circumstances at or around conception and in later life leads to metabolic dysregulation and the development of obesity and diabetes. In this review we highlight three strands of evidence: prospective studies of patterns of growth from birth to adulthood, historical studies of exposure to famine at defined points during gestation and early life, and nutrition intervention studies. We conclude that, while much is still unknown, it is becoming clearer that the combination of early-life undernutrition and later development of obesity is associated with increased risk of diabetes. There is a need to support public health programmes aimed at intergenerational (primordial) prevention of diabetes and other non-communicable disease.