Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research

• Type of Material: Article
• Authors: Jong Woo Lee, Brigham and Women's Hospital; Suzette Laroche, Emory University; Hyunmi Choi, Columbia University; Andres Rodriguez Ruiz, Emory University; Evan Fertig, Atlantic Health Systems-Northeast Regional Epilepsy Group; Jeffrey M. Politsky, Atlantic Health Systems-Northeast Regional Epilepsy Group; Susan T. Herman, Beth Israel Deaconess Hospital; Tobias Loddenkemper, Children's Hospital of Boston; Arnold J. Sansevere, Children's Hospital of Boston; Pearce Korb, Emory University; Nicholas S. Abend, Children's Hospital of Philadelphia; Joshua L. Goldstein, Northwestern University; Saurabh R. Sinha, Duke University; Keith E. Dombrowski, Duke University; Eva K. Ritzl, Johns Hopkins University; Michael B. Westover, Massachusetts General Hospital; Jay R. Gavvala, Northwestern University; Elizabeth E. Gerard, Northwestern University; Sarah E. Schmitt, Hospital of the University of Pennsylvania; Jerzy P. Szaflarski, University of Alabama Birmingham; Kan Ding, UT Southwestern Medical Center; Kevin F. Haas, Vanderbilt University; Richard Buchsbaum, Columbia University; Lawrence J. Hirsch, Yale Medical Center; Courtney J. Wusthoff, Stanford University; Jennifer L. Hopp, University of Maryland; Cecil D. Hahn, University of Toronto
• Language: English
• Date: 2016-04-01
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 by the American Clinical Neurophysiology Society.
• Final Published Version (URL): http://dx.doi.org/10.1097/WNP.0000000000000230
• Title of Journal or Parent Work: Journal of Clinical Neurophysiology
• ISSN: 0736-0258
• Volume: 33
• Issue: 2
• Start Page: 133
• End Page: 140
• Grant/Funding Information: See publication for full funding statement.
• Keywords: CHILDREN; ILL ADULTS; REFRACTORY STATUS EPILEPTICUS; EPILEPSY; TERMINOLOGY; Clinical Neurology; NONCONVULSIVE STATUS EPILEPTICUS; PATTERNS; DISCHARGES; Neurosciences; SEIZURES; Clinical reporting tool; Research database; Continuous EEG monitoring; Science & Technology; Neurosciences & Neurology; CONSENSUS STATEMENT; Life Sciences & Biomedicine
• Research Categories: Biology, Neuroscience

Abstract

Purpose: The rapid expansion of the use of continuous critical care electroencephalogram (cEEG) monitoring and resulting multicenter research studies through the Critical Care EEG Monitoring Research Consortium has created the need for a collaborative data sharing mechanism and repository. The authors describe the development of a research database incorporating the American Clinical Neurophysiology Society standardized terminology for critical care EEG monitoring. The database includes flexible report generation tools that allow for daily clinical use. Methods: Key clinical and research variables were incorporated into a Microsoft Access database. To assess its utility for multicenter research data collection, the authors performed a 21-center feasibility study in which each center entered data from 12 consecutive intensive care unit monitoring patients. To assess its utility as a clinical report generating tool, three large volume centers used it to generate daily clinical critical care EEG reports. Results: A total of 280 subjects were enrolled in the multicenter feasibility study. The duration of recording (median, 25.5 hours) varied significantly between the centers. The incidence of seizure (17.6%), periodic/rhythmic discharges (35.7%), and interictal epileptiform discharges (11.8%) was similar to previous studies. The database was used as a clinical reporting tool by 3 centers that entered a total of 3,144 unique patients covering 6,665 recording days. Conclusions: The Critical Care EEG Monitoring Research Consortium database has been successfully developed and implemented with a dual role as a collaborative research platform and a clinical reporting tool. It is now available for public download to be used as a clinical data repository and report generating tool.