Behavioral trajectories of aging prairie voles (Microtus ochrogaster): Adapting behavior to social context wanes with advanced age

• Type of Material: Article
• Authors: Jeanne M Powell, Emory University; Madison M Garvin, Emory University; Nicholas S Lee, Emory University; Aubrey Kelly, Emory University
• Language: English
• Date: 2022-11-15
• Publisher: PUBLIC LIBRARY SCIENCE
• Publication Version: Final Published Version
• Copyright Statement: © 2022 Powell et al
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1371/journal.pone.0276897
• Title of Journal or Parent Work: PLOS ONE
• Volume: 17
• Issue: 11
• Start Page: e0276897
• End Page: e0276897
• Grant/Funding Information: The authors received no specific funding for this work.
• Keywords: NEOPHOBIA; AFFILIATION; PARTNER-PREFERENCE FORMATION; Science & Technology - Other Topics; STRESS; AGGRESSION; Multidisciplinary Sciences; PLASTICITY; ANXIETY-LIKE BEHAVIOR; ACTIVATION; Science & Technology; FEMALE; WILD
• Research Categories: Psychology, General

Abstract

Several studies using mice have examined the effects of aging on cognitive tasks, as well as sensory and motor functions. However, few studies have examined the influence of aging on social behavior. Prairie voles (Microtus ochrogaster) are a socially monogamous and biparental rodent that live in small family groups and are now among the most popular rodent models for studies examining social behavior. Although the social behavioral trajectories of early-life development in prairie voles have been well-studied, how social behavior may change throughout adulthood remains unknown. Here we examined behavior in virgin male and female prairie voles in four different age groups: postnatal day (PND) 60–80, 140–160, 220–240, and 300–320. All animals underwent testing in a novel object task, a dominance test, a resident-intruder test, and several iterations of social approach and social interaction tests with varying types of social stimuli (i.e., novel same-sex conspecific, novel opposite-sex conspecific, familiar same-sex sibling/cagemate, small group of novel same-sex conspecifics). We found that age influenced neophobia and dominance, but not social approach behavior. Further, we found that young adult, but not older adult, prairie voles adapt prosocial and aggressive behavior relative to social context, and that selective aggression occurs in relation to age even in the absence of a pair bond. Our results suggest that prairie voles calibrate social phenotype in a context-dependent manner in young adulthood and stop adjusting behavior to social context in advanced age, demonstrating that social behavior is plastic not only throughout early development, but also well into adulthood. Together, this study provides insight into age-related changes in social behavior in prairie voles and shows that prairie voles may be a viable model for studying the cognitive and physiological benefits of social relationships and social engagement in advanced age.