Publication

Antipsychotics for Amphetamine Psychosis. A Systematic Review

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Last modified
  • 05/20/2025
Type of Material
Authors
    Dimy Fluyau, Emory UniversityParoma Mitra, New York UniversityKervens Lorthe, Miami Regional University
Language
  • English
Date
  • 2019-10-15
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © Copyright © 2019 Fluyau, Mitra and Lorthe.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-0640
Volume
  • 10
Start Page
  • 740
End Page
  • 740
Supplemental Material (URL)
Abstract
  • Background: Among individuals experiencing amphetamine psychosis, it may be difficult to rule out schizophrenia. The use of antipsychotics for the treatment of amphetamine psychosis is sparse due to possible side effects. Some arguments disfavor their use, stating that the psychotic episode is self-limited. Without treatment, some individuals may not fully recover from the psychosis and may develop full-blown psychosis, emotional, and cognitive disturbance. This review aims to investigate the clinical benefits and risks of antipsychotics for the treatment of amphetamine psychosis. Methods: Electronic search on trials on antipsychotic drugs for amphetamine psychosis from their inception to November 2018 was conducted in PubMed, Scopus, Google Scholar, EBSCOhost, ProQuest, Cochrane Review Database, Medline Ovid, and EMBASE following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The Cochrane risk-of-bias tool assessed the risk of bias, the methodological quality of individual trials was assessed by the Oxford Quality Scoring System, and the quality of evidence for recommendations was judged by the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). The results were synthesized qualitatively and quantitatively. Results: The investigation of six randomized controlled trials of 314 participants showed that aripiprazole, haloperidol, quetiapine, olanzapine, and risperidone were able to reduce or control the psychotic episode (positive and negative symptoms) induced by amphetamine use with no adverse event. Although the side-effect profile of these agents varied, no drug was clinically superior to others. Conclusions: This review suggests that antipsychotics seem to be efficacious for amphetamine psychosis on both positive and negative symptoms. Practitioners need to tailor their use based on risks for side effects individually.
Author Notes
Keywords
Research Categories
  • Health Sciences, Pharmacology
  • Psychology, Clinical

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