Redo_DB: The repurposing drugs in oncology database

• Type of Material: Article
• Authors: Pan Pantziarka, Anticancer Fund; Ciska Verbaanderd, Anticancer Fund; Vidula Sukhatme, GlobalCures Inc; Rica Capistrano I, Anticancer Fund; Sergio Crispino, Anticancer Fund; Bishal Gyawali, Anticancer Fund; Ilse Rooman, Anticancer Fund; An MT Van Nuffel, Anticancer Fund; Lydie Meheus, Anticancer Fund; Vikas Sukhatme, Emory University; Gauthier Bouche, Anticancer Fund
• Language: English
• Date: 2018-12-06
• Publisher: ecancer Global Foundation
• Publication Version: Final Published Version
• Copyright Statement: © The authors.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.3332/ecancer.2018.886
• Title of Journal or Parent Work: ecancermedicalscience
• ISSN: 1754-6605
• Volume: 12
• Start Page: 886
• End Page: 886
• Keywords: online database; repositioning; ReDO project; drug repurposing; cancer drugs
• Research Categories: Health Sciences, Pharmacology; Health Sciences, Oncology

Abstract

Repurposing is a drug development strategy that seeks to use existing medications for new indications. In oncology, there is an increased level of activity looking at the use of non-cancer drugs as possible cancer treatments. The Repurposing Drugs in Oncology (ReDO) project has used a literature-based approach to identify licensed non-cancer drugs with published evidence of anticancer activity. Data from 268 drugs have been included in a database (ReDO_DB) developed by the ReDO project. Summary results are outlined and an assessment of clinical trial activity also described. The database has been made available as an online open-access resource (http://www.redo-project.org/db/).