Combination of serum lipids and cancer antigens as a novel marker for colon cancer diagnosis

• Type of Material: Article
• Authors: Tong Li, Guizhou Provincial People's Hospital; Yinfen Qian, Wudan People's Hospital; Hongling Li, Guizhou Provincial People's Hospital; Jiusheng Deng, Emory University
• Language: English
• Date: 2018-11-20
• Publisher: BMC (part of Springer Nature)
• Publication Version: Final Published Version
• Copyright Statement: © 2018 The Author(s).
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1186/s12944-018-0911-5
• Title of Journal or Parent Work: Lipids in Health and Disease
• ISSN: 1476-511X
• Volume: 17
• Issue: 1
• Start Page: 261
• End Page: 261
• Grant/Funding Information: This study was funded by Chinese National Natural Science Foundation (No.81660080), and the Bureau of Science &Technology of Guiyang City, China (Project No. 29-5-2017).
• Keywords: Cancer antigens; Lipids; Diagnostic marker; Colonic Neoplasms; Carcinoembryonic Antigen; Humans; Serum lipids; Biomarkers, Tumor; Colon cancer; CA-19-9 Antigen; Lipoproteins, HDL
• Research Categories: Health Sciences, Oncology

Abstract

Background: Colon cancer is a malignancy of the large intestine with high mortality and economic burden. Recent studies reveal a new relationship between blood lipids and the risk of cancer. The presents study aims to investigate the combination of serum lipids with cancer antigens as a novel diagnostic marker for colon cancer. Methods: Two hundred of colon cancer patients or healthy subjects were recruited. Serum lipids and cancer antigens such as total cholesterol (TC), high-density lipoprotein (HDL), carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were measured. Results: There were significantly lower level of serum TC or HDL, and significantly higher level of serum CEA or CA19-9 in patients than in healthy subjects. Serum TC or HDL in patients with advanced colon cancer was significantly lower than the ones with early stage disease. The level of serum TC or HDL in patients after surgical removal of colon cancer was significantly higher compared to the ones before surgery, but serum CEA or CA19-9 after surgery was significantly reduced in comparison with the ones before surgery. Combined TC, HDL, CEA and CA19-9 as a diagnostic marker for colon cancer had the highest positive predictive rate in comparison with individual, two or three of the parameters. Conclusions: The combination of serum TC, HDL, CEA and CA19-9 can be used as an effective marker for colon cancer, and offers a novel strategy for clinical diagnosis and monitoring the disease.