Cognitive and neurodevelopmental effects of antiepileptic drugs

• Type of Material: Article
• Authors: Rebecca L. Bromley, University of Manchester; Beth Leeman, Emory University; Gus A. Baker, University of Liverpool; Kimford Meador, Emory University
• Language: English
• Date: 2011-09-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2011.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.yebeh.2011.04.009
• Title of Journal or Parent Work: Epilepsy and Behavior
• ISSN: 1525-5050
• Volume: 22
• Issue: 1
• Start Page: 9
• End Page: 16
• Keywords: PRENATAL EXPOSURE; Psychiatry; TEMPORAL-LOBE EPILEPSY; WORKING-MEMORY LOAD; FOCAL INTERICTAL SPIKES; Antiepileptic drugs; Epilepsy; Science & Technology; Neurosciences & Neurology; Behavioral Sciences; QUALITY-OF-LIFE; Life Sciences & Biomedicine; REACTION-TIME; GAMMA-BAND; IN-UTERO EXPOSURE; Neurodevelopment; Clinical Neurology; Cognitive dysfunction; EPILEPTIFORM ACTIVITY; Pregnancy; CHILDREN BORN
• Research Categories: Health Sciences, Obstetrics and Gynecology; Psychology, Cognitive; Biology, Neuroscience

Abstract

This article primarily represents the contributions of two young investigators to the understanding of the neuropsychological consequences of epilepsy and its treatment. The authors have reviewed two key areas of importance: the complex relationship between cognitive dysfunction and epilepsy and the risks of cognitive dysfunction in children as a consequence of in utero exposure to antiepileptic drug treatment. The work of two young investigators is presented and future research needs are outlined.