Myocardial Bridging Contemporary Understanding of Pathophysiology With Implications for Diagnostic and Therapeutic Strategies

• Type of Material: Article
• Authors: Michel T. Corban, Emory University; Olivia Y. Hung, Emory University; Parham Eshtehardi, Emory University; Emad Rasoul-Arzrumly, Emory University; Michael McDaniel, Emory University; Girum Mekonnen, Emory University; Lucas Timmins, Emory University; Jerre Lutz, Emory University; Robert Guyton, Emory University; Habib Samady, Emory University
• Language: English
• Date: 2014-06-10
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2014 by the American College of Cardiology Foundation Published by Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jacc.2014.01.049
• Title of Journal or Parent Work: Journal of the American College of Cardiology
• ISSN: 0735-1097
• Volume: 63
• Issue: 22
• Start Page: 2346
• End Page: 2355
• Grant/Funding Information: Dr. Hung is supported by the Ruth L. Kirschstein National Research Service Awards training grant (5T32HL007745).; Dr. Mekonnen is supported by a grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health (P01HL101398).; Dr. Samady receives research funding from Volcano Corporation (San Diego, CA) and St. Jude Medical (St. Paul, MN).; Dr. Guyton is a consultant for Medtronic, Inc. (Minneapolis, MN).; Dr. Timmins is supported by the American Heart Association Postdoctoral Fellowship (11POST7210012).
• Keywords: Cardiac & Cardiovascular Systems; ANGIOGRAPHY; Science & Technology; WALL SHEAR-STRESS; myotomy; ATHEROSCLEROSIS; DESCENDING CORONARY-ARTERY; percutaneous coronary intervention; Cardiovascular System & Cardiology; myocardial bridge; SURGICAL-TREATMENT; SYSTOLIC COMPRESSION; intravascular imaging; CLINICAL FOLLOW-UP; intracoronary Doppler velocity and pressure; DOPPLER; coronary wall shear stress; INTRACORONARY ULTRASOUND; Life Sciences & Biomedicine; STENT IMPLANTATION
• Research Categories: Engineering, Biomedical; Health Sciences, Medicine and Surgery

Abstract

Patients with myocardial bridging are often asymptomatic, but this anomaly may be associated with exertional angina, acute coronary syndromes, cardiac arrhythmias, syncope, or even sudden cardiac death. This review presents our understanding of the pathophysiology of myocardial bridging and describes prevailing diagnostic modalities and therapeutic options for this challenging clinical entity.