Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity

• Type of Material: Article
• Authors: Amelia R. Hofstetter, Emory University; Lucy C. Sullivan, University of Melbourne; Aron Lukacher, Emory University; Andrew G. Brooks, University of Melbourne
• Language: English
• Date: 2011-02-01
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 Elsevier Ltd.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.coi.2010.09.009
• Title of Journal or Parent Work: Current Opinion in Immunology
• ISSN: 0952-7915
• Volume: 23
• Issue: 1
• Start Page: 104
• End Page: 110
• Grant/Funding Information: This work was supported by NIH grants R01 CA139220 and R01 CA71971 (AEL), and by the National Health and Medical Research Council (NHMRC).; LCS is supported by a NHMRC Career Development Award.
• Keywords: Life Sciences & Biomedicine; HLA-E; ANTIGEN PRESENTATION; NKT CELLS; CUTTING EDGE; Science & Technology; RECEPTOR; CD8(+) T-CELLS; RECOGNITION; LISTERIA-MONOCYTOGENES INFECTION; ALPHA-CHAIN; Immunology; ENDOCYTIC PATHWAY
• Research Categories: Biology, Microbiology; Health Sciences, Immunology; Health Sciences, Pathology

Abstract

While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.