DNA methylation changes on immune cells in Systemic Lupus Erythematosus

• Type of Material: Article
• Authors: Carolina Hurtado, CES University; Liliana Acevedo Saenz, CES University; Elsa María Vasquez Trespalacios, CES University; Rodrigo Urrego, CES University; Scott Jenks, Emory University; Ignacio Sanz, Emory University; Gloria Vasquez, University of Antioquia
• Language: English
• Date: 2020-02-04
• Publisher: Taylor & Francis Ltd.
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2020 Informa UK Limited.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1080/08916934.2020.1722108
• Title of Journal or Parent Work: Autoimmunity
• Volume: 53
• Issue: 3
• Start Page: 114
• End Page: 121
• Grant/Funding Information: None declared
• Keywords: Down-regulation; Systemic Lupus Erythematosus; Hypomethylation; Autoimmunity; autoimmunity; Expression; Science & Technology; Immunology; Life Sciences & Biomedicine; DNA methylation; Demethylation; Overexpression; CD4(+) T-Cells; CD4+T Cells; B-Cells; Oxidative stress
• Research Categories: Biology, Genetics; Biology, Cell; Biology, Veterinary Science; Health Sciences, Immunology

Abstract

DNA methylation as a process that regulates gene expression is crucial in immune cells biology. Global and gene specific methylation changes have been described in autoimmunity, especially in Systemic Lupus Erythematosus. These changes not only contribute to the understanding of the disease, but also some have been proposed as diagnostic or disease activity biomarkers. The present review compiles the most recent discoveries on this field on each type of immune cells, including specific changes in signalling pathways, genes of interest and its possible applications on diagnosis or treatment.