Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration

• Type of Material: Article
• Authors: Carl R. Rankin, Emory University; Roland S. Hilgarth, Emory University; Giovanna Leoni, Emory University; Mike Kwon, Emory University; Kyle A. Den Beste, Emory University; Charles Parkos, Emory University; Asma Nusrat, Emory University
• Language: English
• Date: 2013-05-24
• Publisher: American Society for Biochemistry and Molecular Biology
• Publication Version: Final Published Version
• Copyright Statement: © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
• Final Published Version (URL): http://www.jbc.org/content/288/21/15229
• Title of Journal or Parent Work: Journal of Biological Chemistry
• ISSN: 0021-9258
• Volume: 288
• Issue: 21
• Start Page: 15229
• End Page: 15239
• Grant/Funding Information: This work was supported by National Institutes of Health Grants R01 DK072564, R01 DK061379, and R01 DK079392 (to C. A. P.) and R01 DK055679 and DK059888 (to A. N.); and Morphology and Tissue Culture Support from Digestive Diseases Minicenter Grant R24 DK064399.
• Keywords: Integrin; β1 Integrin; Endocytosis; Cell Migration; Wound Healing; Annexin 2; Intestinal Epithelium; Annexin A2
• Research Categories: Health Sciences, Pathology; Chemistry, Biochemistry

Abstract

Background: Intestinal epithelial wound closure requires dynamic regulation/turnover of cell-matrix adhesions. Results: Down-regulation of annexin A2 increases cell-matrix adhesion and delays β1 integrin internalization from the plasma membrane. Conclusion: Annexin A2 promotes wound closure by regulating internalization of β1 integrin in migrating epithelial cells. Significance: This study identifies a novel role of annexin A2 in regulating β1 integrin internalization required for intestinal epithelial cell migration.