Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2

• Type of Material: Article
• Authors: Uma B Reddy, Vijayanagara Sri Krishnadevaraya Univ; Nanda Kishore Routhu, Emory University; Anuj Kumar, Cancer Research Center of Lyon (CRCL), INSERM
• Language: English
• Date: 2022-07-01
• Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
• Publication Version: Final Published Version
• Copyright Statement: © 2022 Elsevier Ltd. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.micpath.2022.105512
• Title of Journal or Parent Work: MICROBIAL PATHOGENESIS
• Volume: 168
• Start Page: 105512
• End Page: 105512
• Grant/Funding Information: No funding was involved in the creation of the manuscript.
• Keywords: Microbiology; Immunology; Life Sciences & Biomedicine; Antiviral therapeutics; SARS-CoV-2; Viral replication cycle; CELL ENTRY; Science & Technology; WITHAFERIN; SPIKE PROTEIN; CORONAVIRUS; MAIN PROTEASE; ACE2; TRANSMEMBRANE; PNEUMONIA; COVID-19; Plants; Small molecule inhibitors; RECEPTOR; TMPRSS2
• Research Categories: Health Sciences, Immunology; Biology, Microbiology

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is an illness caused by the new coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has affected public health and the economy globally. Currently approved vaccines and other drug candidates could be associated with several drawbacks which urges developing alternative therapeutic approaches. Aim: To provide a comprehensive review of anti-SARS-CoV-2 activities of plants and their bioactive compounds. Methods: Information was gathered from diverse bibliographic platforms such as PubMed, Google Scholar, and ClinicalTrials.gov registry. Results: The present review highlights the potential roles of crude extracts of plants as well as plant-derived small molecules in inhibiting SARS-CoV-2 infection by targeting viral or host factors essential for viral entry, polyprotein processing, replication, assembly and release. Their anti-inflammatory and antioxidant properties as well as plant-based therapies that are under development in the clinical trial phases-1 to 3 are also covered. Conclusion: This knowledge could further help understanding SARS-CoV-2 infection and anti-viral mechanisms of plant-based therapeutics.