Using the Effects of Youngsters' Eyesight on Quality of Life Questionnaire to Measure Visual Outcomes in Children With Uveitis

• Type of Material: Article
• Authors: Sheila Angeles-Han, Emory University; Steven Yeh, Emory University; Courtney McCracken, Emory University; Kirsten Jenkins, Children's Healthcare of Atlanta; Daneka Stryker, Emory University; Erica Myoung, Emory University; Larry Vogler, Emory University; Kelly Rouster Stevens, Emory University; Scott Lambert, Emory University; Melanie Harrison, Emory University; Sampath Prahalad, Emory University; Carolyn Drews-Botsch, Emory University
• Language: English
• Date: 2015-11-01
• Publisher: Wiley
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015, American College of Rheumatology
• Final Published Version (URL): http://dx.doi.org/10.1002/acr.22627
• Title of Journal or Parent Work: Arthritis Care and Research
• ISSN: 2151-464X
• Volume: 67
• Issue: 11
• Start Page: 1513
• End Page: 1520
• Grant/Funding Information: This study was supported by Award Number K23EY021760 from the National Eye Institute, the Arthritis Foundation New York Chapter, Weill Cornell Medical College Clinical and Translational Science Center (grant UL1RR024996), Emory Egleston Children's Research Center, the Knights Templar Eye Foundation, and also by the Career Development Bridge Funding Award from the American College of Rheumatology Research and Education Foundation and the Arthritis Foundation (Dr. Angeles-Han).; Dr. Prahalad is supported by The National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR060893), The Marcus Foundation Inc. and The Arthritis Foundation.
• Keywords: INSTRUMENT; IMPAIRMENT; ASSOCIATIONS; Rheumatology; VALIDITY; RELIABILITY; Science & Technology; Life Sciences & Biomedicine; INTERMEDIATE; CLASSIFICATION; JUVENILE IDIOPATHIC ARTHRITIS; FUNCTIONAL VISION QUESTIONNAIRE
• Research Categories: Health Sciences, General; Health Sciences, Opthamology

Abstract

Objective: The Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q) is a novel measure of vision-related quality of life (QOL) and function in children. We aim to determine the validity of EYE-Q in childhood uveitis. Methods: We abstracted medical record data on arthritis and uveitis in a convenience sample of children with juvenile idiopathic arthritis (JIA) and/or uveitis. In addition to the EYE-Q, parents and patients completed questionnaires on overall QOL (Pediatric QOL Inventory - PedsQL), and physical functioning (Childhood Health Assessment Questionnaire - CHAQ). Results: Among 57 children (8 JIA, 24 JIA and uveitis, 25 uveitis alone), 102 ocular examinations were performed within 1 month of completing questionnaires. Uveitis patients had bilateral disease (69%), anterior involvement (78%), synechiae (51%) and cataracts (49%). Children with vision loss in their better eye (visual acuity (VA) 20/50 or worse) had worse EYE-Q (p = 0.006), and PedsQL (p = 0.028), but not CHAQ scores. The EYE-Q moderately correlated with logMAR VA (rs = −0.43), PedsQL (rs = 0.43) and CHAQ (rs = −0.45), but was not correlated with anterior chamber cells or intraocular pressure. The PedsQL and CHAQ did not correlate with VA or cells. There were strong correlations between the parent and child EYE-Q (rs = 0.62). Cronbach's α for the child report was 0.91. The EYE-Q had strong test-retest reliability (rs=0.75). Conclusion: The EYE-Q may be an important tool in the assessment of visual outcomes in childhood uveitis and an improvement over general measures in detecting changes in vision-related function.