Ischemic Heart Disease in Young Women JACC Review Topic of the Week

• Type of Material: Article
• Authors: Margo B Minissian, Cedars-Sinai Medical Center; Puja Mehta, Emory University; Sharonne N Hayes, Mayo Clinic; Ki Park, University of Florida; Janet Wei, Cedars-Sinai Medical Center; Noel Bairey C Merz, Cedars-Sinai Medical Center; Leslie Cho, Case Western Reserve University; Annabelle Santos Volgman, Rush Coll Med; Islam Y Elgendy, University of Kentucky; Mamas Mamas, Keele University; Melinda B Davis, University of Michigan; Harmony R Reynolds, NYU School of Medicine; Kelly Epps, Inova Heart and Vascular Institute; Kathryn Lindley, Vanderbilt University; Malissa Wood, Massachusetts General Hospital; Odayme Quesada, Cedars-Sinai Medical Center; Gregory Piazza, Harvard Medical School; Carl J Pepine, University of Florida
• Language: English
• Date: 2022-08-29
• Publisher: ELSEVIER SCIENCE INC
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2022 Published by Elsevier on Behalf of The American College of Cardiology Foundation. All Rights Reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.jacc.2022.01.057
• Title of Journal or Parent Work: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• Volume: 80
• Issue: 10
• Start Page: 1014
• End Page: 1022
• Keywords: NATIONAL HEART; SEX-DIFFERENCES; Science & Technology; ischemic; ANGINA; CORONARY-ARTERY SPASM; women; Life Sciences & Biomedicine; REACTIVITY; SECONDARY PREVENTION; MICROVASCULAR DYSFUNCTION; GENDER-DIFFERENCES; heart; Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; ACUTE MYOCARDIAL-INFARCTION; OUTCOMES; disease; mortality

Abstract

The Cardiovascular Disease in Women Committee of the American College of Cardiology convened a working group to develop a consensus regarding the continuing rise of mortality rates in young women aged 35 to 54 years. Heart disease mortality rates in young women continue to increase. Young women have increased mortality secondary to ischemic heart disease (IHD) compared with comparably aged men and similar mortality to that observed among older women. The authors reviewed the published evidence, including observational and mechanistic/translational data, and identified knowledge gaps pertaining to young women. This paper provides clinicians with pragmatic, evidence-based management strategies for young women at risk for IHD. Next-step research opportunities are outlined. This report presents highlights of the working group review and a summary of suggested research directions to advance the IHD field in the next decade.