Analysis of BMT CTN-0201 and-0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

• Type of Material: Article
• Authors: Armin Rashidi, University of Minnesota; Ryan Shanley, University of Minnesota; Claudio Anasetti, H. Lee Moffitt Cancer Center and Research Institute; Edmund Waller, Emory University; Bart L. Scott, University of Washington; Bruce R. Blazar, University of Minnesota; Daniel J. Weisdorf, University of Minnesota
• Language: English
• Date: 2019-03-01
• Publisher: NATURE PUBLISHING GROUP
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2018, Springer Nature Limited
• Final Published Version (URL): http://dx.doi.org/10.1038/s41409-018-0331-1
• Title of Journal or Parent Work: BONE MARROW TRANSPLANTATION
• Volume: 54
• Issue: 3
• Start Page: 490
• End Page: 493
• Grant/Funding Information: Enrollment support was provided by DKMS Germany.; Research reported in this publication was also supported by NIH grant P30 CA77598 utilizing the Biostatistics and Bioinformatics Core shared resource of the Masonic Cancer Center, University of Minnesota and by the by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114.; Support for the primary clinical trials was provided to the Blood and Marrow Transplant Clinical Trials Network by grant #U10HL069294 from the National Heart, Lung, and Blood Institute and the National Cancer Institute.; Armin Rashidi was supported by an American Blood and Marrow Transplantation Young Investigator Award.; The Department of Navy, Office of Navy Research, and the National Marrow Donor Program also provided support.
• Keywords: Biophysics; Oncology; MARROW; Transplantation; Immunology; GENETIC POLYMORPHISMS; Life Sciences & Biomedicine; REPLICATION; Hematology; Science & Technology; HOST; BLOOD
• Research Categories: Health Sciences, Immunology; Health Sciences, Oncology; Health Sciences, Medicine and Surgery

Abstract

Letter to the Editor: Regenerating islet-derived protein 3 alpha (REG3A) is a C-type lectin constitutively expressed and apically secreted by Paneth cells at high levels, with powerful bactericidal activity against gram-positive bacteria of the gut. By limiting the number of mucosal adherent bacteria, REG3A separates gut microbiota and epithelium, promoting intestinal tolerance to microbial antigens and reducing bacterial translocation. Circulating REG3A has been used as a biomarker of gastrointestinal GVHD, and has been used to predict response to therapy and non-relapse mortality (NRM). A recent study reported a novel association between a single nucleotide polymorphism (SNP rs7588571; minor allele A with frequency 0.49) in the putative promotor region of REG3A and extensive chronic GVHD (ecGVHD) [...]