Neuroinvasive cryptococcosis in an immunocompetent patient with a negative spinal fluid cryptococcus antigen.

• Type of Material: Article
• Authors: Rocio Garcia Santibanez, Emory University; Veenu Gill, Mount Sinai Beth Israel; Stanley Yancovitz, Mount Sinai Beth Israel; DeWitt Pyburn, Mount Sinai Beth Israel
• Language: English
• Date: 2015
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2015 Rocio C. Garcia-Santibanez et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1155/2015/857539
• Title of Journal or Parent Work: Case Reports in Infectious Diseases
• ISSN: 2090-6625
• Volume: 2015
• Start Page: 857539
• End Page: 857539
• Research Categories: Health Sciences, Immunology; Health Sciences, General

Abstract

58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed antifungal therapy. Serum Cryptococcus antigen titer decreased. He had a full neurological recovery.