Reproducibility and Reliability of Anti-3-[F-18]FACBC Uptake Measurements in Background Structures and Malignant Lesions on Follow-Up PET-CT in Prostate Carcinoma: an Exploratory Analysis

• Type of Material: Article
• Authors: Oluwaseun Odewole, Emory University; Oyeladun A. Oyenuga, Emory University; Funmilayo Tade, Emory University; Bital Savir Baruch, Emory University; Peter Nieh, Emory University; Viraj Master, Emory University; Zhengjia Chen, Emory University; Xiaojing Wang, Emory University; Ashesh Jani, Emory University; Leah M. Bellamy, Emory University; Raghuveer Halkar, Emory University; Mark Goodman, Emory University; David Schuster, Emory University
• Language: English
• Date: 2015-04-01
• Publisher: Springer Verlag (Germany)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2014, World Molecular Imaging Society
• Final Published Version (URL): http://dx.doi.org/10.1007/s11307-014-0797-1
• Title of Journal or Parent Work: Molecular Imaging and Biology
• ISSN: 1536-1632
• Volume: 17
• Issue: 2
• Start Page: 277
• End Page: 283
• Grant/Funding Information: This study was funded by the National Institutes of Health (5R01CA129356) and (P50 CA 128301), and Georgia Cancer Coalition.
• Keywords: TUMORS; FACBC; POSITRON-EMISSION-TOMOGRAPHY; Prostate cancer; Reliability; STANDARDIZED UPTAKE VALUES; Reproducibility; Science & Technology; FDG-PET; CLINICAL-APPLICATIONS; CANCER; ANTI-1-AMINO-3-F-18-FLUOROCYCLOBUTANE-1-CARBOXYLIC ACID; PET-CT; Life Sciences & Biomedicine; F-18-FDG PET; Radiology, Nuclear Medicine & Medical Imaging; ONCOLOGY; NORMAL-TISSUES; Radiotracer
• Research Categories: Health Sciences, Radiology; Health Sciences, Oncology

Abstract

Purpose: The aim of this study is to examine the reproducibility of anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-3-[18F]FACBC) quantitative measurements in key background structures and untreated malignant lesions. Procedures: Retrospective review of 14 patients who underwent follow-up anti-3-[18F]FACBC positron emission tomography-X-ray computed tomography (PET-CT) for prostate carcinoma recurrence. Standard uptake values (SUV) were measured in both original and follow-up scans in key background structures and untreated malignant lesions. Absolute and percent mean difference in SUV between scans and interclass correlation coefficients (ICC) were also computed. Results: Mean (±SD, range) scan interval was 17.4 months (±7.1, 4–29). %Mean difference in SUVmean was <20 % in background structures with low absolute differences. ICCs were >0.6 except for early-phase blood pool (ICC=0.4). SUVmax in malignant lesions without interim therapy increased or remained stable over time. Conclusions: Despite variable time interval between scans, FACBC PET-CT demonstrates acceptable reproducibility in key background structures. Untreated malignant lesions showed stable or increased uptake over time. A formal test-retest study is planned.