Publication

Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment

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Last modified
  • 05/15/2025
Type of Material
Authors
    Xiaoping Lin, Sun Yat-Sen University Cancer CenterZizheng Xiao, Sun Yat-Sen University Cancer CenterTao Chen, Sun Yat-Sen University Cancer CenterSteven Huan Liang, Emory UniversityHuiqin Guo, Beijing Shijitan Hospital
Language
  • English
Date
  • 2020-03-06
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2020 Lin, Xiao, Chen, Liang and Guo.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 10
Start Page
  • 317
End Page
  • 317
Grant/Funding Information
  • This work was supported by the Fund of Natural Science Foundation of Guangdong Province, China, No. 2018A030310239.
Abstract
  • Malignant cells support tumor proliferation and progression by adopting to metabolic changes. Tumor cells altered metabolism by increasing glucose uptake and fermentation of glucose to lactate, even in the aerobic state and the presence of functioning mitochondria. Glucose metabolism in tumor plasticity has attracted great interests by clinicians and scientists in the past decades. This review discusses the previous and emerging researches on the tumor plasticity altered by changing glucose metabolism in different cancer cells, including cancer stem cells (CSCs). In addition, we summarize the rising applications of glucose metabolism in tumor diagnosis and treatment. Our objective is to direct future investigation on this altered metabolic phenotype and its application in patient care.
Author Notes
Keywords
Research Categories
  • Biology, Neuroscience
  • Health Sciences, Oncology
  • Health Sciences, Radiology

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