Cross-talk between T and B cells in the Germinal Center following transplantation

• Type of Material: Article
• Authors: Jean Kwun, Duke University Medical Center; Miriam Manook, Duke University Medical Center; Eugenia Page, Emory University; Christopher Burghuber, Medical University of Vienna; Jungjoo Hong, Korea Research Institute of Bioscience and Biotechnology; Stuart Knechtle, Emory University
• Language: English
• Date: 2017-04-01
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2016 Wolters Kluwer Health, Inc. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1097/TP.0000000000001588
• Title of Journal or Parent Work: Transplantation
• ISSN: 0041-1337
• Volume: 101
• Issue: 4
• Start Page: 704
• End Page: 712
• Grant/Funding Information: The work in this paper is supported in part by grants: NIH U01 AI074635 (SJK), NIH U19 AI051731 (SJK), and AHA Enduring Hearts Foundation Research Award 15SDG25710165 (JK).
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Crosstalk between B and T cells in transplantation is increasingly recognized as being important in the alloimmune response. T cell activation of B cells occurs by a 3-stage pathway, culminating with costimulation signals. We review the distinct T cell subtypes required for B-cell activation and discuss the formation of the germinal center (GC) after transplantation, with particular reference to the repopulation of the GC after depletional induction, and the subsequent effect of immunosuppressive manipulation of T cell-B cell interactions. In addition, ectopic GCs are seen in transplantation, but their role is not fully understood. Therapeutic options to target T cell-B cell interactions are of considerable interest, both as immunosuppressive tools, and to aid in the further understanding of these important alloimmune mechanisms.