Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA)

• Type of Material: Article
• Authors: Arvind K Pandey, Johns Hopkins University; Michael J Blaha, Johns Hopkins Ciccarone Preventive Cardiology Center; Kavita Sharma, Johns Hopkins Ciccarone Preventive Cardiology Center; Juan Rivera, Johns Hopkins Ciccarone Preventive Cardiology Center; Matthew J Budoff, University of California, Los Angeles; Ron Blankstein, Brigham & Women's Hospital; Mouaz Al-Mallah, Henry Ford Hospital; Nathan D Wong, University of California, Irvine; Leslee Shaw, Emory University; Jeffrey Carr, Wake Forest University; Daniel O'Leary, St Elizabeth's Medical Center; Joao AC Lima, Johns Hopkins Ciccarone Preventive Cardiology Center; Moyses Szklo, Johns Hopkins University; Roger S Blumenthal, Johns Hopkins Ciccarone Preventive Cardiology Center; Khurram Nasir, Johns Hopkins Ciccarone Preventive Cardiology Center
• Language: English
• Date: 2014-02-01
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2013 Published by Elsevier Inc.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.atherosclerosis.2013.11.042
• Title of Journal or Parent Work: Atherosclerosis
• ISSN: 0021-9150
• Volume: 232
• Issue: 2
• Start Page: 369
• End Page: 376
• Grant/Funding Information: This research was supported by contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute.
• Keywords: Coronary calcium; Peripheral Vascular Disease; Science & Technology; RISK-FACTORS; YOUNG-ADULTS CARDIA; Family history; ASYMPTOMATIC INDIVIDUALS; Cardiac & Cardiovascular Systems; MYOCARDIAL-INFARCTION; PARENTAL HISTORY; CARDIOVASCULAR RISK; BEAM COMPUTED-TOMOGRAPHY; AMERICAN-COLLEGE; Cardiovascular System & Cardiology; Life Sciences & Biomedicine; EXPERT CONSENSUS DOCUMENT; Subclinical atherosclerosis; LOWERING THERAPY
• Research Categories: Health Sciences, Radiology; Health Sciences, Medicine and Surgery; Health Sciences, Epidemiology

Abstract

Objective: We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). Background: MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary heart disease (CHD) and CAC incidence or progression has not been described previously. Methods: A total of 5099 participants had detailed information about family history of CHD (late versus premature and parental versus sibling history). The mean time between CAC scans was 3.1±1.3 years. The association of late versus premature family history was assessed against CAC change using multivariate regression model adjusted for demographics and cardiac risk factors. Results: A family history of premature CHD was associated with an odds ratio (OR) of 1.55 (p<0.01) for incident development of CAC after adjusting for risk factors and demographics. A premature family history was associated with 14.4 units (p<0.01) greater volume scores compared to those with no family history in similarly adjusted models by median regression analysis. A combined parental and sibling family history was associated with the greatest incidence and progression in demographic-adjusted models. Caucasians demonstrated the most consistent predictive relationship between family history of premature CHD and incidence (p<0.01) and progression (p<0.05) of CAC, though no significant interaction with ethnicity was noted. Conclusions: Family history of premature CHD is associated with enhanced development and progression of subclinical disease, independent of other risk factors, in a multiethnic, population-based study.