Publication

Association of Cerebral Artery Stenosis With Post-stroke Depression at Discharge and 3 Months After Ischemic Stroke Onset

Downloadable Content

Persistent URL
Last modified
  • 07/08/2025
Type of Material
Authors
    Xiuli Qiu, Tongji Medical CollegeJinfeng Miao, Tongji Medical CollegeYan Lan, Tongji Medical CollegeWenzhe Sun, Tongji Medical CollegeYuxi Chen, Johns Hopkins School of MedicineZiqin Cao, Emory UniversityGuo Li, Tongji Medical CollegeXin Zhao, Tongji Medical CollegeZhou Zhu, Tongji Medical CollegeSuiqang Zhu, Tongji Medical College
Language
  • English
Date
  • 2020-11-25
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2020 Qiu, Miao, Lan, Sun, Chen, Cao, Li, Zhao, Zhu and Zhu.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 11
Start Page
  • 585201
End Page
  • 585201
Grant/Funding Information
  • This work was financially supported by the National Key R&D Program of China [grant number 2017YFC1310000], the Fundamental Research Funds for the Central Universities [grant number 2018KFYXMPT015], and Hubei Technological Innovation Special Fund [grant number 2019ACA132]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ZZ and SZ had full access to all the data in the study and had final responsibility for the decision to submit for publication.
Supplemental Material (URL)
Abstract
  • Background: Post-stroke depression (PSD) is one of the most common complications after stroke, which seriously affects patients' recovery outcome. Although vascular depression has been extensively studied, the relationship between cerebral artery stenosis and PSD has not been clarified so far. Methods: Two hundred ninety-eight patients with ischemic stroke (72 women, 226 men) with computed tomography angiography (CTA) or magnetic resonance angiography (MRA) were included in this study. Cerebral artery stenosis ≥50% was used as the cut-off value. The DSM-V diagnostic criteria of PSD was met and the 17-item Hamilton Rating Scale for Depression (HAMD-17) score over 7 at discharge and 3 months after stroke onset was regarded as the primary outcome. The χ2-test, Mann-Whitney U-test, and t-test were used to check for statistical significance. Results: At discharge, Barthel index (p < 0.001), left middle cerebral artery stenosis (p = 0.019), drinking history (p = 0.048), basilar artery stenosis (p = 0.037) were significantly associated with PSD. At 3 months after ischemic stroke onset, Barthel index (p = 0.011), left middle cerebral artery stenosis (p = 0.012), female gender (p = 0.001) were significantly associated with PSD. Conclusions: The findings demonstrated that left middle cerebral artery and basilar artery stenosis are associated with PSD. It was suggested that cerebral artery stenosis was a risk factor of PSD and should be recognized and intervened early. Registration Number: ChiCTR-ROC-17013993.
Author Notes
Keywords
Research Categories
  • Health Sciences, Medicine and Surgery

Tools

Relations

In Collection:

Items

Thumbnail Title File Description Date Uploaded Visibility Actions
file details Publication File - w290z.pdf Primary Content 2025-05-28 Public Download