Serologic aspects of COVID-19: Recommendations for use in the clinical setting

• Type of Material: Article
• Authors: Omar K Alkhairy, King Abdulaziz Medical City - Riyadh; Ziad Memish, Emory University; Ali H Hajeer, King Abdulaziz Medical City - Riyadh
• Language: English
• Date: 2021-05-01
• Publisher: Elsevier Ltd
• Publication Version: Final Published Version
• Copyright Statement: © 2021 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.tmaid.2021.102046
• Title of Journal or Parent Work: Travel Medicine and Infectious Disease
• Volume: 41
• Start Page: 102046
• End Page: 102046
• Grant/Funding Information: None.
• Keywords: COVID-19; Humans; SARS-CoV-2; Immunoglobulin G; Antibodies, Viral
• Research Categories: Health Sciences, Pathology; Health Sciences, General

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a new zoonotic coronavirus that was detected in humans in December 2019, in Wuhan, China [1]. SARS-CoV-2 uses its spike (S) protein to bind to the SARS-CoV-1 receptor, ACE2, to enter the cell, a process that is facilitated by the priming of the serine protease TMPRSS2 [2]. Making a diagnosis of COVID-19 infection may require clinical presentation, radiology, and laboratory testing. In COVID-19 patients, SARS‐CoV‐2 virus was detected in urine, blood, anal, and oropharyngeal swabs, suggesting the virus is invading multi-organs and is not restricted to the respiratory system [3]. Proper sampling technique is essential for obtaining an adequate specimen.